| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0734 | SERP0735 | SERP0734 | SERP0735 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoesterase, putative; Identified by match to protein family HMM PF01143; match to protein family HMM TIGR00040. | 0.962 |
| SERP0734 | murI | SERP0734 | SERP0733 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.985 |
| SERP0735 | SERP0734 | SERP0735 | SERP0734 | Phosphoesterase, putative; Identified by match to protein family HMM PF01143; match to protein family HMM TIGR00040. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.962 |
| SERP0735 | murI | SERP0735 | SERP0733 | Phosphoesterase, putative; Identified by match to protein family HMM PF01143; match to protein family HMM TIGR00040. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.857 |
| ald | murI | SERP1272 | SERP0733 | Alanine dehydrogenase; Catalyzes the reversible reductive amination of pyruvate to L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer (By similarity). Belongs to the AlaDH/PNT family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.802 |
| femC | gltD | SERP0876 | SERP0109 | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | 0.985 |
| femC | gluD | SERP0876 | SERP0546 | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.970 |
| femC | murI | SERP0876 | SERP0733 | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.875 |
| femC | purQ | SERP0876 | SERP0653 | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.909 |
| femC | rocA | SERP0876 | SERP2128 | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; Identified by similarity to EGAD:22788; match to protein family HMM PF00171; match to protein family HMM TIGR01237; Belongs to the aldehyde dehydrogenase family. RocA subfamily. | 0.908 |
| gltD | femC | SERP0109 | SERP0876 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | 0.985 |
| gltD | gluD | SERP0109 | SERP0546 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.935 |
| gltD | murI | SERP0109 | SERP0733 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.800 |
| gltD | purQ | SERP0109 | SERP0653 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
| gltD | rocA | SERP0109 | SERP2128 | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; Identified by similarity to EGAD:22788; match to protein family HMM PF00171; match to protein family HMM TIGR01237; Belongs to the aldehyde dehydrogenase family. RocA subfamily. | 0.909 |
| gluD | femC | SERP0546 | SERP0876 | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...] | 0.970 |
| gluD | gltD | SERP0546 | SERP0109 | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase, small subunit; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01317. | 0.935 |
| gluD | murI | SERP0546 | SERP0733 | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.843 |
| gluD | purQ | SERP0546 | SERP0653 | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.905 |
| gluD | rocA | SERP0546 | SERP2128 | Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; Identified by similarity to EGAD:22788; match to protein family HMM PF00171; match to protein family HMM TIGR01237; Belongs to the aldehyde dehydrogenase family. RocA subfamily. | 0.970 |
