| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0203 | gmk | SERP0203 | SERP0776 | Identified by match to protein family HMM PF01712. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.917 |
| apt | gmk | SERP1198 | SERP0776 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.941 |
| apt | guaA | SERP1198 | SERP0070 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.980 |
| apt | guaC | SERP1198 | SERP0906 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.925 |
| apt | hpt | SERP1198 | SERP0149 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to EGAD:18056; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.932 |
| apt | relA-2 | SERP1198 | SERP1196 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.659 |
| apt | xpt | SERP1198 | SERP0067 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.923 |
| gmk | SERP0203 | SERP0776 | SERP0203 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Identified by match to protein family HMM PF01712. | 0.917 |
| gmk | apt | SERP0776 | SERP1198 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.941 |
| gmk | guaA | SERP0776 | SERP0070 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.984 |
| gmk | guaC | SERP0776 | SERP0906 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.916 |
| gmk | hpt | SERP0776 | SERP0149 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to EGAD:18056; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.933 |
| gmk | ndk | SERP0776 | SERP1037 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.930 |
| gmk | pyk | SERP0776 | SERP1261 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Identified by similarity to EGAD:37614; match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.942 |
| gmk | relA-2 | SERP0776 | SERP1196 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.924 |
| gmk | rpoZ | SERP0776 | SERP0777 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.996 |
| gmk | xpt | SERP0776 | SERP0067 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.954 |
| guaA | apt | SERP0070 | SERP1198 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.980 |
| guaA | gmk | SERP0070 | SERP0776 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.984 |
| guaA | guaC | SERP0070 | SERP0906 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.998 |