STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mscLLarge conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (116 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
  
 0.768
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
    0.608
ispA
Geranyltranstransferase; Identified by similarity to SP:Q08291; match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family.
      
 0.546
SERP0920
Choline/carnitine/betaine transporter; Identified by match to protein family HMM PF02028; match to protein family HMM TIGR00842; Belongs to the BCCT transporter (TC 2.A.15) family.
     
 0.543
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.512
dnaK
dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
     
 0.484
SERP0590
Na+/H+ exchanger family protein, putative; Identified by match to protein family HMM PF00999; match to protein family HMM PF02080; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
     
 0.461
secG
Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family.
   
  
 0.457
lcdH
3-hydroxyacyl-CoA dehydrogenase family protein; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine.
      
 0.456
prsA-2
Protein export protein PrsA, putative; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins.
      
 0.406
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
Server load: high (84%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.