Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
trpCIndole-3-glycerol phosphate synthase; Identified by similarity to EGAD:18396; match to protein family HMM PF00218; Belongs to the TrpC family. (262 aa)    
Predicted Functional Partners:
trpE
Anthranilate synthase component I; Identified by match to protein family HMM PF00425; match to protein family HMM PF04715.
 
 0.999
trpG
Anthranilate synthase component II; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.999
trpF
N-(5'phosphoribosyl)-anthranilate isomerase; Identified by similarity to EGAD:40212; match to protein family HMM PF00697; Belongs to the TrpF family.
 
 
 0.999
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 0.999
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 
 0.999
pabA
Para-aminobenzoate synthase, glutamine amidotransferase, component II; Identified by similarity to EGAD:15630; match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
 0.993
hisIE
phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family.
  
  
 0.856
SERP1297
Chorismate mutase/phospho-2-dehydro-3-deoxyheptonate aldolase; Identified by similarity to EGAD:21270; match to protein family HMM PF00793; match to protein family HMM PF01817; match to protein family HMM TIGR01361; match to protein family HMM TIGR01801.
  
  
 0.766
SERP0629
Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543.
 
   
 0.740
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
Server load: medium (54%) [HD]