Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
arlRDNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. (219 aa)    
Predicted Functional Partners:
arlS
Sensor histidine kinase ArlS; Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).
 
 0.999
hssS
Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
 
 
 0.900
saeS
Sensor histidine kinase SaeS; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR (By similarity).
 
 
 0.864
graS
Sensor histidine kinase; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity).
 
 
 0.860
srrB
Sensor histidine kinase SrrB; Identified by similarity to GP:7839534; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
 0.844
phoR
Sensory box histidine kinase PhoR; Identified by similarity to EGAD:18590; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
 0.813
SERP2205
Sensor histidine kinase, putative; Identified by match to protein family HMM PF02518.
 
   0.781
yycG
Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR.
 
 0.764
lytS
Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism.
      
 0.645
kdpD
Sensor histidine kinase KdpD; Identified by similarity to EGAD:18674; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF02702.
 
 
 0.578
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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