node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP0035 | fhs | SERP0035 | SERP1295 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
SERP0035 | fmt | SERP0035 | SERP0782 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.942 |
SERP0035 | folA-1 | SERP0035 | SERP1002 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.936 |
SERP0035 | folC | SERP0035 | SERP1227 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to EGAD:12279; similarity to EGAD:42028; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.442 |
SERP0035 | gcvT | SERP0035 | SERP1102 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.956 |
SERP0035 | glyA | SERP0035 | SERP1719 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
SERP0035 | purH | SERP0035 | SERP0658 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.944 |
SERP0035 | purN | SERP0035 | SERP0657 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.943 |
SERP0035 | thyA-1 | SERP0035 | SERP1003 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.939 |
SERP0035 | thyA-2 | SERP0035 | SERP1582 | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Thymidylate synthase; Identified by match to protein family HMM PF00303. | 0.418 |
fhs | SERP0035 | SERP1295 | SERP0035 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | 0.951 |
fhs | folA-1 | SERP1295 | SERP1002 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.919 |
fhs | folC | SERP1295 | SERP1227 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to EGAD:12279; similarity to EGAD:42028; match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.670 |
fhs | gcvT | SERP1295 | SERP1102 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.960 |
fhs | glyA | SERP1295 | SERP1719 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
fhs | purH | SERP1295 | SERP0658 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.980 |
fhs | purN | SERP1295 | SERP0657 | Formate--tetrahydrofolate ligase; Identified by similarity to EGAD:40369; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.960 |
fmt | SERP0035 | SERP0782 | SERP0035 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Homocysteine S-methyltransferase/5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | 0.942 |
fmt | folA-1 | SERP0782 | SERP1002 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.919 |
fmt | gcvT | SERP0782 | SERP1102 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |