STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pbp3Penicillin-binding protein 3; Identified by similarity to OMNI:SA1609; match to protein family HMM PF00905; match to protein family HMM PF03717. (696 aa)    
Predicted Functional Partners:
pbp2
Penicillin-binding protein 2; Identified by match to protein family HMM PF00905; match to protein family HMM PF00912.
 
 
 0.993
mgt
Transglycosylase domain protein; Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate; Belongs to the glycosyltransferase 51 family.
 
 
 0.960
SERP1294
Transglycosylase domain protein; Identified by match to protein family HMM PF00912.
 
 
 0.957
pbp1
Penicillin-binding protein 1; Identified by similarity to OMNI:NTL01SA1064; match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793.
  
  
0.956
SERP1691
Cell division protein, FtsW/RodA/SpoVE family; Identified by match to protein family HMM PF01098; Belongs to the SEDS family.
 
 
 0.927
mecA
Penicillin-binding protein 2; Identified by similarity to EGAD:16370; match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF05223.
 
  
0.925
mreC
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
 
 
 0.877
SERP0703
Cell division protein, FtsW/RodA/SpoVE family; Identified by match to protein family HMM PF01098; Belongs to the SEDS family.
 
 
 0.871
gpsB
Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
 
  
 0.857
ezrA
Conserved hypothetical protein; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
   
 0.825
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.