node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP2046 | SERP2065 | SERP2046 | SERP2065 | Exopolyphosphatase; Identified by match to protein family HMM PF02541. | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | 0.900 |
SERP2046 | relA-1 | SERP2046 | SERP0586 | Exopolyphosphatase; Identified by match to protein family HMM PF02541. | GTP pyrophosphokinase; Identified by match to protein family HMM PF04607. | 0.900 |
SERP2046 | relA-2 | SERP2046 | SERP1196 | Exopolyphosphatase; Identified by match to protein family HMM PF02541. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.928 |
SERP2065 | SERP2046 | SERP2065 | SERP2046 | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | Exopolyphosphatase; Identified by match to protein family HMM PF02541. | 0.900 |
SERP2065 | ndk | SERP2065 | SERP1037 | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
SERP2065 | pyk | SERP2065 | SERP1261 | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | Pyruvate kinase; Identified by similarity to EGAD:37614; match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.900 |
SERP2065 | relA-1 | SERP2065 | SERP0586 | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | GTP pyrophosphokinase; Identified by match to protein family HMM PF04607. | 0.918 |
SERP2065 | relA-2 | SERP2065 | SERP1196 | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.914 |
dtd | lytH | SERP1195 | SERP1194 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | N-acetylmuramoyl-L-alanine amidase, family 3; Probably involved in cell-wall metabolism; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | 0.883 |
dtd | relA-2 | SERP1195 | SERP1196 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.929 |
gmk | ndk | SERP0776 | SERP1037 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.930 |
gmk | nrdE | SERP0776 | SERP0397 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.907 |
gmk | nrdF-1 | SERP0776 | SERP0398 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase 2, beta subunit; Identified by similarity to EGAD:37758; match to protein family HMM PF00268. | 0.904 |
gmk | pyk | SERP0776 | SERP1261 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Identified by similarity to EGAD:37614; match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.942 |
gmk | relA-2 | SERP0776 | SERP1196 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.924 |
lytH | dtd | SERP1194 | SERP1195 | N-acetylmuramoyl-L-alanine amidase, family 3; Probably involved in cell-wall metabolism; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.883 |
lytH | relA-2 | SERP1194 | SERP1196 | N-acetylmuramoyl-L-alanine amidase, family 3; Probably involved in cell-wall metabolism; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.904 |
ndk | SERP2065 | SERP1037 | SERP2065 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Conserved hypothetical protein; Identified by similarity to OMNI:SA2518; match to protein family HMM PF04607. | 0.900 |
ndk | gmk | SERP1037 | SERP0776 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.930 |
ndk | nrdE | SERP1037 | SERP0397 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.908 |