STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoRSensory box histidine kinase PhoR; Identified by similarity to EGAD:18590; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (565 aa)    
Predicted Functional Partners:
phoP
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486.
 0.999
yycF
DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR.
 
 0.903
saeR
DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
 
 0.838
arlR
DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR.
 
 0.831
srrA
DNA-binding response regulator SrrA; Identified by similarity to EGAD:14175; similarity to OMNI:SA1535; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.828
hssR
DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
 
 0.820
graR
DNA-binding response regulator; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).
 
 0.811
pstB
Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
     
 0.787
kdeP
DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.786
icd
Isocitrate dehydrogenase, NADP-dependent; Identified by similarity to EGAD:23750; match to protein family HMM PF00180; match to protein family HMM TIGR00183.
       0.773
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.