STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sspAGlutamyl endopeptidase precursor SspA; Exhibits a significant hydrolytic activity for the carbonyl side of glutamic acid. Shows activity toward human fibronectin and type 1 collagen (By similarity). (282 aa)    
Predicted Functional Partners:
sspB
Cysteine protease precursor SspB; Cysteine protease able to cleave elastin, insulin, myoglobin, fibronectin, fibrinogen, HMW-kininogen, alpha-1-protease inhibitor and alpha-1-antitrypsin. Along with other extracellular proteases may contribute to the colonization and infection of human tissues (By similarity).
  
  
 0.913
scpA
Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
      
 0.818
sepA
Extracellular elastase precursor; Extracellular zinc metalloprotease.
  
  
 0.817
SERP2401
Serine protease; Identified by match to protein family HMM PF00089; Belongs to the peptidase S1B family.
      
 0.612
atlE
Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
      
 0.535
SERP2286
Phosphonate ABC transporter, phosphonate-binding protein.
   
    0.503
SERP1396
PTS system, IIC component, putative; Identified by match to protein family HMM PF02378.
       0.432
ebh
Cell wall associated fibronectin-binding protein; Identified by similarity to OMNI:SA1472; match to protein family HMM PF01468; match to protein family HMM PF02370; match to protein family HMM PF02524; match to protein family HMM PF04508; match to protein family HMM PF04650; match to protein family HMM TIGR01168.
      
 0.430
hlb
Beta-hemolysin; Identified by similarity to OMNI:SA2003; match to protein family HMM PF03372.
   
  
 0.411
SERP2263
N-acetylmuramoyl-L-alanine amidase domain protein; Identified by match to protein family HMM PF01832; match to protein family HMM PF05257.
    
 
 0.402
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.