STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
perRTranscriptional regulator, Fur family; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity). Belongs to the Fur family. (150 aa)    
Predicted Functional Partners:
SERP1399
D-isomer specific 2-hydroxyacid dehydrogenase family protein; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
    0.877
bcp
Bacterioferritin comigratory protein; Identified by match to protein family HMM PF00578.
     
 0.833
hemL-2
Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P71084; match to protein family HMM PF00202; match to protein family HMM TIGR00713.
       0.770
ahpC
Alkyl hydroperoxide reductase, C subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.749
SERP1402
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA1742.
       0.709
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
   0.594
rpoD
RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.545
ftnA
Ferritin family protein; Iron-storage protein.
     
 0.515
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
  
 0.493
sarZ
Transcriptional regulator, MarR family; Identified by match to protein family HMM PF01047.
   
  
 0.477
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.