STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vraSSensor histidine kinase VraS; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates VraR by phosphorylation (By similarity). (348 aa)    
Predicted Functional Partners:
vraR
DNA-binding response regulator VraR; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis.
 
 0.999
SERP1424
Conserved hypothetical protein; Identified by similarity to OMNI:SA1944.
 
  
 0.981
SERP1425
Conserved hypothetical protein; Identified by similarity to OMNI:SA1945.
     
 0.909
SERP1384
DNA-binding response regulator, LuxR family; Identified by match to protein family HMM PF00072; match to protein family HMM PF00196.
 
 
 0.870
nreC
Transcriptional regulatory protein DegU, putative; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).
 
 
 0.870
SERP0889
DNA-binding response regulator, LuxR family; Identified by match to protein family HMM PF00072; match to protein family HMM PF00196.
 
 
 0.866
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
       0.796
SERP0888
Sensor histidine kinase, putative; Identified by match to protein family HMM PF02518.
  
     0.772
SERP1427
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA1766.
       0.745
mgt
Transglycosylase domain protein; Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate; Belongs to the glycosyltransferase 51 family.
   
  
 0.591
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.