node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP1156 | tdk | SERP1156 | SERP1726 | comE operon protein 2; Identified by similarity to EGAD:23914; match to protein family HMM PF00383. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.927 |
SERP1156 | thyA-1 | SERP1156 | SERP1003 | comE operon protein 2; Identified by similarity to EGAD:23914; match to protein family HMM PF00383. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.923 |
SERP1156 | tmk | SERP1156 | SERP0120 | comE operon protein 2; Identified by similarity to EGAD:23914; match to protein family HMM PF00383. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
SERP1722 | prfA | SERP1722 | SERP1725 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.869 |
SERP1722 | prmC | SERP1722 | SERP1724 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Modification methylase, HemK family; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.981 |
SERP1722 | ptpB | SERP1722 | SERP1721 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Phosphotyrosine protein phosphatase; Dephosphorylates the phosphotyrosine-containing proteins. Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.883 |
SERP1722 | tdk | SERP1722 | SERP1726 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.866 |
cdd | deoD | SERP1135 | SERP1747 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.926 |
cdd | pdp | SERP1135 | SERP1744 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Pyrimidine-nucleoside phosphorylase; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.973 |
cdd | tdk | SERP1135 | SERP1726 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.932 |
deoD | cdd | SERP1747 | SERP1135 | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.926 |
deoD | pdp | SERP1747 | SERP1744 | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | Pyrimidine-nucleoside phosphorylase; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.987 |
deoD | tdk | SERP1747 | SERP1726 | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.925 |
pdp | cdd | SERP1744 | SERP1135 | Pyrimidine-nucleoside phosphorylase; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.973 |
pdp | deoD | SERP1744 | SERP1747 | Pyrimidine-nucleoside phosphorylase; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.987 |
pdp | tdk | SERP1744 | SERP1726 | Pyrimidine-nucleoside phosphorylase; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.926 |
prfA | SERP1722 | SERP1725 | SERP1722 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.869 |
prfA | prmC | SERP1725 | SERP1724 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Modification methylase, HemK family; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.996 |
prfA | ptpB | SERP1725 | SERP1721 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Phosphotyrosine protein phosphatase; Dephosphorylates the phosphotyrosine-containing proteins. Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.868 |
prfA | tdk | SERP1725 | SERP1726 | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Thymidine kinase; Identified by similarity to EGAD:23194; match to protein family HMM PF00265. | 0.965 |