STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tcaRTranscriptional regulator TcaR; Identified by similarity to OMNI:SA2353; match to protein family HMM PF01047. (151 aa)    
Predicted Functional Partners:
tcaA
tcaA protein; Plays a major role in decreasing resistance to glycopeptide antibiotics; Belongs to the TcaA family.
       0.777
rsbU
Sigma factor B regulator protein; Identified by similarity to GP:1729794.
   
  
 0.770
icaR
Intercellular adhesion regulator; Represses transcription of the icaADBC operon necessary for biofilm production.
      
 0.755
sarA
Staphylococcal accessory regulator A; Identified by similarity to EGAD:42500; match to protein family HMM TIGR01889.
      
 0.620
SERP1950
Membrane protein, putative; Identified by match to protein family HMM PF02698.
  
    0.531
sarX
Staphylococcal accessory regulator family; Identified by match to protein family HMM TIGR01889.
      
 0.485
icaA
Intercellular adhesion protein A; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity.
   
  
 0.437
rpoF
RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
      
 0.416
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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