| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0015 | hrtB | SERP0015 | SERP1952 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.579 |
| SERP0021 | hrtB | SERP0021 | SERP1952 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.570 |
| SERP0314 | hrtB | SERP0314 | SERP1952 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.570 |
| SERP1004 | hrtB | SERP1004 | SERP1952 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.718 |
| SERP2204 | hrtB | SERP2204 | SERP1952 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.570 |
| hrtA | hrtB | SERP1951 | SERP1952 | ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.999 |
| hrtA | hssR | SERP1951 | SERP1953 | ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.966 |
| hrtA | hssS | SERP1951 | SERP1954 | ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.957 |
| hrtB | SERP0015 | SERP1952 | SERP0015 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.579 |
| hrtB | SERP0021 | SERP1952 | SERP0021 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.570 |
| hrtB | SERP0314 | SERP1952 | SERP0314 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.570 |
| hrtB | SERP1004 | SERP1952 | SERP1004 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.718 |
| hrtB | SERP2204 | SERP1952 | SERP2204 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.570 |
| hrtB | hrtA | SERP1952 | SERP1951 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | 0.999 |
| hrtB | hssR | SERP1952 | SERP1953 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.958 |
| hrtB | hssS | SERP1952 | SERP1954 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.957 |
| hrtB | nirD | SERP1952 | SERP1989 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to EGAD:30823; match to protein family HMM PF00355. | 0.517 |
| hrtB | pheT | SERP1952 | SERP0722 | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.641 |
| hssR | hrtA | SERP1953 | SERP1951 | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | 0.966 |
| hssR | hrtB | SERP1953 | SERP1952 | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | ABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.958 |