STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hrtBABC transporter, permease protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). (350 aa)    
Predicted Functional Partners:
hrtA
ABC transporter, ATP-binding protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity).
 
 0.999
hssR
DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
     
 0.958
hssS
Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
 
  
 0.957
SERP1004
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
 
 
 0.718
pheT
phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.641
SERP0015
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
 
 0.579
SERP0021
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
 
 0.570
SERP0314
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
 
 0.570
SERP2204
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
 
 0.570
nirD
Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to EGAD:30823; match to protein family HMM PF00355.
   
  
 0.517
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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