Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SERP1973General stress protein 26, putative; Identified by similarity to EGAD:107318. (140 aa)    
Predicted Functional Partners:
SERP2437
Lipoprotein, putative.
  
    0.658
SERP1269
Universal stress protein family; Identified by similarity to OMNI:SA1753; match to protein family HMM PF00582.
  
    0.599
SERP2066
Conserved hypothetical protein; Identified by similarity to EGAD:108077.
  
    0.593
rsbW
Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
  
    0.575
SERP1972
Transcriptional regulator, AraC family; Identified by match to protein family HMM PF00165.
  
    0.571
rsbV
Anti-anti-sigma factor RsbV; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family.
  
    0.511
SERP0480
Identified by match to protein family HMM PF02566; Belongs to the OsmC/Ohr family.
 
    0.509
SERP0494
Conserved hypothetical protein; Identified by similarity to OMNI:SA0912; match to protein family HMM PF05532; Belongs to the UPF0337 (CsbD) family.
  
    0.492
ptpA
Phosphotyrosine protein phosphatase; Dephosphorylates the phosphotyrosine-containing proteins. Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
   
    0.487
SERP1286
Identified by match to protein family HMM PF02566.
 
    0.485
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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