Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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nreCTranscriptional regulatory protein DegU, putative; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity). (218 aa)    
Predicted Functional Partners:
nreB
Sensor histidine kinase, putative; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity).
 
 0.999
SERP1385
Sensor histidine kinase; Identified by match to protein family HMM PF02518.
 
 
 0.922
SERP1983
Conserved hypothetical protein.
 
 
 0.912
SERP0888
Sensor histidine kinase, putative; Identified by match to protein family HMM PF02518.
 
 
 0.906
narT
Nitrite extrusion protein; Probably required for nitrate uptake under anoxic conditions. Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity).
     
 0.887
vraS
Sensor histidine kinase VraS; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates VraR by phosphorylation (By similarity).
 
 
 0.869
narG
Respiratory nitrate reductase, alpha subunit; Identified by similarity to EGAD:30702; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
  
 0.790
narJ
Respiratory nitrate reductase, delta subunit; Identified by similarity to EGAD:30705; match to protein family HMM PF02613; match to protein family HMM TIGR00684.
 
   
 0.736
narI
Respiratory nitrate reductase, gamma subunit; Identified by similarity to EGAD:30704; match to protein family HMM PF02665; match to protein family HMM TIGR00351.
     
 0.670
narH
Respiratory nitrate reductase, beta subunit; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01660.
     
 0.669
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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