Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
narIRespiratory nitrate reductase, gamma subunit; Identified by similarity to EGAD:30704; match to protein family HMM PF02665; match to protein family HMM TIGR00351. (225 aa)    
Predicted Functional Partners:
narJ
Respiratory nitrate reductase, delta subunit; Identified by similarity to EGAD:30705; match to protein family HMM PF02613; match to protein family HMM TIGR00684.
 
  
 0.999
narH
Respiratory nitrate reductase, beta subunit; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01660.
 
 0.999
narG
Respiratory nitrate reductase, alpha subunit; Identified by similarity to EGAD:30702; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
 0.999
nirD
Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to EGAD:30823; match to protein family HMM PF00355.
  
 
 0.994
nirB
Nitrite reductase [NAD(P)H], large subunit; Identified by similarity to EGAD:30822; match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.978
narT
Nitrite extrusion protein; Probably required for nitrate uptake under anoxic conditions. Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity).
 
  
 0.955
SERP1983
Conserved hypothetical protein.
 
     0.833
nreB
Sensor histidine kinase, putative; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity).
       0.740
nreC
Transcriptional regulatory protein DegU, putative; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).
     
 0.670
SERP1988
uroporphyrinogen-III methylase SirB, putative; Identified by similarity to GP:4433641; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family.
  
    0.608
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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