Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nirBNitrite reductase [NAD(P)H], large subunit; Identified by similarity to EGAD:30822; match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (801 aa)    
Predicted Functional Partners:
nirD
Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to EGAD:30823; match to protein family HMM PF00355.
 
 0.999
narG
Respiratory nitrate reductase, alpha subunit; Identified by similarity to EGAD:30702; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
 
 0.990
narH
Respiratory nitrate reductase, beta subunit; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01660.
  
 
 0.979
narI
Respiratory nitrate reductase, gamma subunit; Identified by similarity to EGAD:30704; match to protein family HMM PF02665; match to protein family HMM TIGR00351.
  
 
 0.978
SERP1988
uroporphyrinogen-III methylase SirB, putative; Identified by similarity to GP:4433641; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family.
  
 0.936
femC
Glutamine synthetase FemC; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. U [...]
    
 0.926
gluD
Glutamate dehydrogenase, NAD-specific; Identified by similarity to EGAD:20751; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.915
SERP0325
Flavohemoprotein, putative; Identified by match to protein family HMM PF00042; match to protein family HMM PF00970; Belongs to the globin family.
 
  
 0.885
narT
Nitrite extrusion protein; Probably required for nitrate uptake under anoxic conditions. Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity).
 
  
 0.813
nirR
Transcriptional regulator NirR; Identified by similarity to GP:4433637.
  
  
 0.753
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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