Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nirRTranscriptional regulator NirR; Identified by similarity to GP:4433637. (239 aa)    
Predicted Functional Partners:
SERP2188
Siroheme synthase, putative; Identified by match to protein family HMM TIGR01470.
  
  
 0.919
SERP1988
uroporphyrinogen-III methylase SirB, putative; Identified by similarity to GP:4433641; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family.
 
  
 0.859
nirD
Nitrite reductase [NAD(P)H], small subunit; Identified by similarity to EGAD:30823; match to protein family HMM PF00355.
  
  
 0.858
SERP2189
uroporphyrin-III C-methyltransferase, putative; Identified by similarity to EGAD:15084; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family.
 
  
 0.798
SERP1993
Hypothetical protein; Identified by Glimmer2; putative.
       0.773
nirB
Nitrite reductase [NAD(P)H], large subunit; Identified by similarity to EGAD:30822; match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.753
cysH
Phosophoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.681
cysC
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
  
    0.668
cysI
Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.654
narH
Respiratory nitrate reductase, beta subunit; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01660.
  
    0.653
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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