node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP0095 | cysE | SERP0095 | SERP0169 | Identified by match to protein family HMM PF01053. | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | 0.856 |
SERP0095 | hom | SERP0095 | SERP0897 | Identified by match to protein family HMM PF01053. | Homoserine dehydrogenase; Identified by similarity to EGAD:7108; match to protein family HMM PF00742; match to protein family HMM PF03447. | 0.856 |
SERP0095 | ilvA | SERP0095 | SERP1673 | Identified by match to protein family HMM PF01053. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.830 |
SERP0095 | sdhA | SERP0095 | SERP2094 | Identified by match to protein family HMM PF01053. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to EGAD:154938; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.812 |
SERP0095 | sdhB | SERP0095 | SERP2095 | Identified by match to protein family HMM PF01053. | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by similarity to SP:P33074; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.812 |
SERP0095 | thrB | SERP0095 | SERP0899 | Identified by match to protein family HMM PF01053. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.829 |
SERP2080 | ilvA | SERP2080 | SERP1673 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.817 |
SERP2080 | sdhA | SERP2080 | SERP2094 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to EGAD:154938; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.821 |
SERP2080 | sdhB | SERP2080 | SERP2095 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by similarity to SP:P33074; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.821 |
SERP2080 | trpA | SERP2080 | SERP0943 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.812 |
SERP2080 | trpB | SERP2080 | SERP0942 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.812 |
cysE | SERP0095 | SERP0169 | SERP0095 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Identified by match to protein family HMM PF01053. | 0.856 |
cysE | glyA | SERP0169 | SERP1719 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.844 |
cysE | hom | SERP0169 | SERP0897 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Homoserine dehydrogenase; Identified by similarity to EGAD:7108; match to protein family HMM PF00742; match to protein family HMM PF03447. | 0.863 |
cysE | ilvA | SERP0169 | SERP1673 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.816 |
cysE | sdhA | SERP0169 | SERP2094 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to EGAD:154938; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.908 |
cysE | sdhB | SERP0169 | SERP2095 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by similarity to SP:P33074; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.908 |
cysE | thrB | SERP0169 | SERP0899 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.829 |
cysE | trpA | SERP0169 | SERP0943 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.814 |
cysE | trpB | SERP0169 | SERP0942 | Serine acetyltransferase; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.813 |