Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SERP2206DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (221 aa)    
Predicted Functional Partners:
SERP2205
Sensor histidine kinase, putative; Identified by match to protein family HMM PF02518.
  0.997
graS
Sensor histidine kinase; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity).
 
   0.890
SERP2203
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
 
     0.876
hssS
Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
 
 
 0.820
saeS
Sensor histidine kinase SaeS; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR (By similarity).
 
 
 0.791
SERP2204
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
 
   
 0.788
phoR
Sensory box histidine kinase PhoR; Identified by similarity to EGAD:18590; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
 0.713
arlS
Sensor histidine kinase ArlS; Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).
 
 
 0.705
SERP0020
ABC transporter, permease protein; Identified by similarity to OMNI:NTL01BH0754; match to protein family HMM PF02687.
     0.698
SERP0315
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
     0.690
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.