| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0915 | bhp | SERP0915 | SERP2392 | IS256-like transposase; Required for the transposition of the insertion element. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.760 |
| SERP1259 | bhp | SERP1259 | SERP2392 | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.760 |
| SERP1584 | bhp | SERP1584 | SERP2392 | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.760 |
| SERP1587 | bhp | SERP1587 | SERP2392 | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.760 |
| SERP2011 | bhp | SERP2011 | SERP2392 | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.760 |
| atlE | bhp | SERP0636 | SERP2392 | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | 0.765 |
| atlE | fbe | SERP0636 | SERP0775 | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | Fibronectin/fibrinogen binding protein; Identified by similarity to OMNI:SA1220; match to protein family HMM PF05670; match to protein family HMM PF05833. | 0.846 |
| atlE | icaA | SERP0636 | SERP2293 | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | Intercellular adhesion protein A; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity. | 0.837 |
| atlE | icaB | SERP0636 | SERP2295 | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | Intercellular adhesion protein B; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. In fact, the IcaB deacetylase converts 15 to 20% of the GlcNAc residues of PNAG to glucosamine. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. Deacetylation of the polymer is also essential for key virulence mechanisms of S.epidermidis, namely biof [...] | 0.774 |
| atlE | icaD | SERP0636 | SERP2294 | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | Intercellular adhesion protein D; Necessary for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Is required for full IcaA N- acetylglucosaminyltransferase activity. | 0.687 |
| bhp | SERP0915 | SERP2392 | SERP0915 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | IS256-like transposase; Required for the transposition of the insertion element. | 0.760 |
| bhp | SERP1259 | SERP2392 | SERP1259 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | 0.760 |
| bhp | SERP1584 | SERP2392 | SERP1584 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | 0.760 |
| bhp | SERP1587 | SERP2392 | SERP1587 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | 0.760 |
| bhp | SERP2011 | SERP2392 | SERP2011 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | IS256-like transposase; Identified by similarity to EGAD:22488; match to protein family HMM PF00872. | 0.760 |
| bhp | atlE | SERP2392 | SERP0636 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | Bifunctional autolysin; Endohydrolysis of the di-N-acetylchitobiosyl unit in high- mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis (By similarity); In the C-terminal section; belongs to the glycosyl hydrolase 73 family. | 0.765 |
| bhp | fbe | SERP2392 | SERP0775 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | Fibronectin/fibrinogen binding protein; Identified by similarity to OMNI:SA1220; match to protein family HMM PF05670; match to protein family HMM PF05833. | 0.756 |
| bhp | icaA | SERP2392 | SERP2293 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | Intercellular adhesion protein A; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity. | 0.790 |
| bhp | icaB | SERP2392 | SERP2295 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | Intercellular adhesion protein B; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. In fact, the IcaB deacetylase converts 15 to 20% of the GlcNAc residues of PNAG to glucosamine. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. Deacetylation of the polymer is also essential for key virulence mechanisms of S.epidermidis, namely biof [...] | 0.623 |
| bhp | icaD | SERP2392 | SERP2294 | Cell wall associated biofilm protein; Identified by match to protein family HMM PF00746; match to protein family HMM PF00801; match to protein family HMM PF04650; match to protein family HMM PF05345; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168. | Intercellular adhesion protein D; Necessary for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Is required for full IcaA N- acetylglucosaminyltransferase activity. | 0.722 |