| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP2488 | kdeP | SERP2488 | SERP2490 | Hypothetical protein; Identified by Glimmer2; putative. | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.610 |
| SERP2488 | kdpA | SERP2488 | SERP2487 | Hypothetical protein; Identified by Glimmer2; putative. | K+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.554 |
| SERP2488 | kdpB | SERP2488 | SERP2486 | Hypothetical protein; Identified by Glimmer2; putative. | K+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | 0.524 |
| SERP2488 | kdpC | SERP2488 | SERP2485 | Hypothetical protein; Identified by Glimmer2; putative. | K+-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | 0.504 |
| SERP2488 | kdpD | SERP2488 | SERP2489 | Hypothetical protein; Identified by Glimmer2; putative. | Sensor histidine kinase KdpD; Identified by similarity to EGAD:18674; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF02702. | 0.610 |
| arlR | hssS | SERP0989 | SERP1954 | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.900 |
| arlR | kdpD | SERP0989 | SERP2489 | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | Sensor histidine kinase KdpD; Identified by similarity to EGAD:18674; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF02702. | 0.578 |
| hssR | hssS | SERP1953 | SERP1954 | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.996 |
| hssR | kdpD | SERP1953 | SERP2489 | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | Sensor histidine kinase KdpD; Identified by similarity to EGAD:18674; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF02702. | 0.636 |
| hssS | arlR | SERP1954 | SERP0989 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | 0.900 |
| hssS | hssR | SERP1954 | SERP1953 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | DNA-binding response regulator; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.996 |
| hssS | kdeP | SERP1954 | SERP2490 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.816 |
| hssS | kdpD | SERP1954 | SERP2489 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | Sensor histidine kinase KdpD; Identified by similarity to EGAD:18674; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF02702. | 0.577 |
| hssS | phoP | SERP1954 | SERP1256 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.837 |
| hssS | saeR | SERP1954 | SERP0365 | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity). | 0.910 |
| kdeP | SERP2488 | SERP2490 | SERP2488 | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | Hypothetical protein; Identified by Glimmer2; putative. | 0.610 |
| kdeP | hssS | SERP2490 | SERP1954 | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | Sensor histidine kinase; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of HrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.816 |
| kdeP | kdpA | SERP2490 | SERP2487 | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | K+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.752 |
| kdeP | kdpB | SERP2490 | SERP2486 | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | K+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | 0.718 |
| kdeP | kdpC | SERP2490 | SERP2485 | DNA-binding response regulator KdeP; Identified by similarity to EGAD:91700; match to protein family HMM PF00072; match to protein family HMM PF00486. | K+-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | 0.719 |
