| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| arlR | yycG | SERP0989 | SERP2533 | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.764 |
| fmtC | phoP | SERP0930 | SERP1256 | fmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine [...] | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.644 |
| fmtC | yycG | SERP0930 | SERP2533 | fmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine [...] | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.633 |
| fmtC | yycH | SERP0930 | SERP2532 | fmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine [...] | yycH protein; Identified by similarity to GP:6689208. | 0.554 |
| phoP | fmtC | SERP1256 | SERP0930 | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486. | fmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine [...] | 0.644 |
| phoP | yycG | SERP1256 | SERP2533 | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486. | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.821 |
| rimM | yycG | SERP0805 | SERP2533 | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.665 |
| saeR | yycG | SERP0365 | SERP2533 | DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity). | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.704 |
| srrA | yycG | SERP1055 | SERP2533 | DNA-binding response regulator SrrA; Identified by similarity to EGAD:14175; similarity to OMNI:SA1535; match to protein family HMM PF00072; match to protein family HMM PF00486. | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.785 |
| yycF | yycG | SERP2534 | SERP2533 | DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR. | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 0.999 |
| yycF | yycH | SERP2534 | SERP2532 | DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR. | yycH protein; Identified by similarity to GP:6689208. | 0.962 |
| yycF | yycI | SERP2534 | SERP2531 | DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR. | yycI protein; Identified by similarity to OMNI:SA0022. | 0.967 |
| yycF | yycJ | SERP2534 | SERP2530 | DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR. | Identified by match to protein family HMM PF00753. | 0.776 |
| yycG | arlR | SERP2533 | SERP0989 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | 0.764 |
| yycG | fmtC | SERP2533 | SERP0930 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | fmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine [...] | 0.633 |
| yycG | phoP | SERP2533 | SERP1256 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | Alkaline phosphatase synthesis transcriptional regulatory protein PhoP; Identified by similarity to EGAD:18490; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.821 |
| yycG | rimM | SERP2533 | SERP0805 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. | 0.665 |
| yycG | saeR | SERP2533 | SERP0365 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | DNA-binding response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS. Probably functions as a transcriptional regulator via a specific DNA- binding domain, recognizing motifs near the promoter sequences of target genes (By similarity). | 0.704 |
| yycG | srrA | SERP2533 | SERP1055 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | DNA-binding response regulator SrrA; Identified by similarity to EGAD:14175; similarity to OMNI:SA1535; match to protein family HMM PF00072; match to protein family HMM PF00486. | 0.785 |
| yycG | yycF | SERP2533 | SERP2534 | Sensory box histidine kinase YycG; Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR. | DNA-binding response regulator YycF; Member of the two-component regulatory system WalK/WalR. | 0.999 |
