pfp protein (Agrobacterium fabrum) - STRING interaction network

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pfp

Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (403 aa)

Predicted Functional Partners:

pgi

0.986

talB

0.951

tktA

0.938

manC

0.927

Atu3740

0.927

pykA

0.922

scrK

0.918

tktB

0.906

tkt

0.904

Atu3311

0.900

Your Current Organism:

Agrobacterium fabrum

NCBI taxonomy Id: 176299
Other names: A. fabrum str. C58, Agrobacterium fabrum str. C58, Agrobacterium tumefaciens (strain C58 / ATCC 33970), Agrobacterium tumefaciens (strain C58), Agrobacterium tumefaciens str. C58, Agrobacterium tumefaciens str. C58 (Cereon), Agrobacterium tumefaciens str. C58 (Dupont), Agrobacterium tumefaciens str. C58 (U. Washington), Rhizobium radiobacter str. C58 (Cereon), Rhizobium radiobacter str. C58 (Dupont), Rhizobium radiobacter str. C58 (U. Washington)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atu3311	manC	Atu3311	Atu3353	Phosphomannose isomerase.	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	0.989
Atu3311	pfp	Atu3311	Atu2115	Phosphomannose isomerase.	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.900
Atu3311	pgi	Atu3311	Atu0404	Phosphomannose isomerase.	Glucose-6-phosphate isomerase.	0.904
Atu3311	scrK	Atu3311	Atu0401	Phosphomannose isomerase.	Fructokinase.	0.904
Atu3740	pfp	Atu3740	Atu2115	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.927
Atu3740	pgi	Atu3740	Atu0404	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Glucose-6-phosphate isomerase.	0.917
Atu3740	pykA	Atu3740	Atu3762	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.876
Atu3740	talB	Atu3740	Atu4464	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.936
Atu3740	tkt	Atu3740	Atu1902	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transketolase.	0.900
Atu3740	tktA	Atu3740	Atu3736	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.947
Atu3740	tktB	Atu3740	Atu1901	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transketolase.	0.900
manC	Atu3311	Atu3353	Atu3311	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	Phosphomannose isomerase.	0.989
manC	pfp	Atu3353	Atu2115	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.927
manC	pgi	Atu3353	Atu0404	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	Glucose-6-phosphate isomerase.	0.956
manC	scrK	Atu3353	Atu0401	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	Fructokinase.	0.913
pfp	Atu3311	Atu2115	Atu3311	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	Phosphomannose isomerase.	0.900
pfp	Atu3740	Atu2115	Atu3740	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	Fructose bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.927
pfp	manC	Atu2115	Atu3353	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family.	0.927
pfp	pgi	Atu2115	Atu0404	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	Glucose-6-phosphate isomerase.	0.986
pfp	pykA	Atu2115	Atu3762	Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.922

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