STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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proC-2Pyrroline-5-carboxylate reductase. (260 aa)    
Predicted Functional Partners:
putA
Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
 
 0.606
dapA-4
Dihydrodipicolinate synthase; Belongs to the DapA family.
 
   
 0.593
Atu3958
Oxidoreductase.
  
  
 0.564
Atu4684
Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity.
 
   
 0.554
Atu0398
Conserved hypothetical protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp, which would allow A.tumefaciens to grow on t4LHyp as a sole carbon source. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Displays no proline racemase activity.
 
   
 0.553
Atu4678
ABC transporter, substrate binding protein (amino acid).
  
  
 0.550
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
     
 0.544
Atu3953
Conserved hypothetical protein; Belongs to the proline racemase family.
     
 0.544
Atu3961
Transcriptional regulator, GntR family.
  
   
 0.533
Atu4676
Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.
  
   
 0.521
Your Current Organism:
Agrobacterium fabrum
NCBI taxonomy Id: 176299
Other names: A. fabrum str. C58, Agrobacterium fabrum str. C58, Agrobacterium tumefaciens (strain C58 / ATCC 33970), Agrobacterium tumefaciens (strain C58), Agrobacterium tumefaciens str. C58, Agrobacterium tumefaciens str. C58 (Cereon), Agrobacterium tumefaciens str. C58 (Dupont), Agrobacterium tumefaciens str. C58 (U. Washington), Rhizobium radiobacter str. C58 (Cereon), Rhizobium radiobacter str. C58 (Dupont), Rhizobium radiobacter str. C58 (U. Washington)
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