Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Atu4120Mandelate racemase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (372 aa)    
Predicted Functional Partners:
Atu2815
Conserved hypothetical protein.
 
   
 0.570
Atu3817
Dehydratase.
 
  
 0.557
Atu4118
Transcriptional regulator, GntR family.
       0.504
Atu3527
Conserved hypothetical protein.
 
   
 0.484
aroE-2
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
      
 0.470
Atu3138
Conserved hypothetical protein; Catalyzes the isomerization of D-galactaro-1,5-lactone to D- galactaro-1,4-lactone. This is a step in the oxidative degradation pathway of D-galacturonate, which allows A.tumefaciens to utilize D- galacturonate as a sole carbon source.
     
 0.467
udh
Conserved hypothetical protein; Catalyzes the oxidation of D-galacturonate and D-glucuronate to galactarate and D-glucarate, respectively. In fact, in water solution the substrate D-galacturonate is predominantly in pyranosic form whose beta anomer is converted by the enzyme to D-galactaro-1,5- lactone; in solution, this reaction product rearranges to the more stable D-galactaro-1,4-lactone. Makes part of the oxidative degradation pathway of D-galacturonate, which allows A.tumefaciens to utilize D- galacturonate as a sole carbon source. Cannot use NADP(+) instead of NAD(+) as cosubstra [...]
      
 0.466
Atu3972
Conserved hypothetical protein.
      
 0.466
glcD
Glycolate oxidase subunit.
     
 0.462
pdxA
Pyridoxal phosphate biosynthesis protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
     
 0.454
Your Current Organism:
Agrobacterium fabrum
NCBI taxonomy Id: 176299
Other names: A. fabrum str. C58, Agrobacterium fabrum str. C58, Agrobacterium tumefaciens (strain C58 / ATCC 33970), Agrobacterium tumefaciens (strain C58), Agrobacterium tumefaciens str. C58, Agrobacterium tumefaciens str. C58 (Cereon), Agrobacterium tumefaciens str. C58 (Dupont), Agrobacterium tumefaciens str. C58 (U. Washington), Rhizobium radiobacter str. C58 (Cereon), Rhizobium radiobacter str. C58 (Dupont), Rhizobium radiobacter str. C58 (U. Washington)
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