Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dadA-2D-amino acid dehydrogenase, small subunit. (413 aa)    
Predicted Functional Partners:
Atu4684
Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity.
 
   
 0.910
Atu4680
ABC transporter, membrane spanning protein (amino acid).
 
     0.903
Atu4678
ABC transporter, substrate binding protein (amino acid).
 
  
 0.880
Atu4681
ABC transporter, nucleotide binding/ATPase protein (amino acid).
 
     0.880
Atu3953
Conserved hypothetical protein; Belongs to the proline racemase family.
 
   
 0.852
dapA-6
Dihydrodipicolinate synthase; Belongs to the DapA family.
 
   
 0.838
Atu4679
ABC transporter, membrane spanning protein (amino acid).
 
     0.835
Atu0398
Conserved hypothetical protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp, which would allow A.tumefaciens to grow on t4LHyp as a sole carbon source. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Displays no proline racemase activity.
 
   
 0.817
Atu4676
Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.
 
   
 0.777
Atu4683
Conserved hypothetical protein.
 
     0.772
Your Current Organism:
Agrobacterium fabrum
NCBI taxonomy Id: 176299
Other names: A. fabrum str. C58, Agrobacterium fabrum str. C58, Agrobacterium tumefaciens (strain C58 / ATCC 33970), Agrobacterium tumefaciens (strain C58), Agrobacterium tumefaciens str. C58, Agrobacterium tumefaciens str. C58 (Cereon), Agrobacterium tumefaciens str. C58 (Dupont), Agrobacterium tumefaciens str. C58 (U. Washington), Rhizobium radiobacter str. C58 (Cereon), Rhizobium radiobacter str. C58 (Dupont), Rhizobium radiobacter str. C58 (U. Washington)
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