Atu4684 protein (Agrobacterium fabrum) - STRING interaction network

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Atu4684

Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity. (342 aa)

Predicted Functional Partners:

Atu4683

0.991

dadA-2

0.910

Atu4678

0.770

dapA-6

0.769

Atu4676

0.720

Atu3364

0.688

arcB

0.662

Atu4680

0.629

Atu4679

0.615

Atu4681

0.579

Your Current Organism:

Agrobacterium fabrum

NCBI taxonomy Id: 176299
Other names: A. fabrum str. C58, Agrobacterium fabrum str. C58, Agrobacterium tumefaciens (strain C58 / ATCC 33970), Agrobacterium tumefaciens (strain C58), Agrobacterium tumefaciens str. C58, Agrobacterium tumefaciens str. C58 (Cereon), Agrobacterium tumefaciens str. C58 (Dupont), Agrobacterium tumefaciens str. C58 (U. Washington), Rhizobium radiobacter str. C58 (Cereon), Rhizobium radiobacter str. C58 (Dupont), Rhizobium radiobacter str. C58 (U. Washington)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atu3364	Atu4684	Atu3364	Atu4684	D-amino acid dehydrogenase.	Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity.	0.688
Atu3364	dapA-6	Atu3364	Atu4675	D-amino acid dehydrogenase.	Dihydrodipicolinate synthase; Belongs to the DapA family.	0.608
Atu4676	Atu4678	Atu4676	Atu4678	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	ABC transporter, substrate binding protein (amino acid).	0.820
Atu4676	Atu4679	Atu4676	Atu4679	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	ABC transporter, membrane spanning protein (amino acid).	0.507
Atu4676	Atu4680	Atu4676	Atu4680	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	ABC transporter, membrane spanning protein (amino acid).	0.496
Atu4676	Atu4681	Atu4676	Atu4681	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	ABC transporter, nucleotide binding/ATPase protein (amino acid).	0.408
Atu4676	Atu4683	Atu4676	Atu4683	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	Conserved hypothetical protein.	0.842
Atu4676	Atu4684	Atu4676	Atu4684	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity.	0.720
Atu4676	arcB	Atu4676	Atu3949	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	Ornithine cyclodeaminase.	0.479
Atu4676	dadA-2	Atu4676	Atu4682	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	D-amino acid dehydrogenase, small subunit.	0.777
Atu4676	dapA-6	Atu4676	Atu4675	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	Dihydrodipicolinate synthase; Belongs to the DapA family.	0.682
Atu4678	Atu4676	Atu4678	Atu4676	ABC transporter, substrate binding protein (amino acid).	Putative malate dehydrogenase; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source; Belongs to the LDH2/MDH2 oxidoreductase family.	0.820
Atu4678	Atu4679	Atu4678	Atu4679	ABC transporter, substrate binding protein (amino acid).	ABC transporter, membrane spanning protein (amino acid).	0.983
Atu4678	Atu4680	Atu4678	Atu4680	ABC transporter, substrate binding protein (amino acid).	ABC transporter, membrane spanning protein (amino acid).	0.982
Atu4678	Atu4681	Atu4678	Atu4681	ABC transporter, substrate binding protein (amino acid).	ABC transporter, nucleotide binding/ATPase protein (amino acid).	0.979
Atu4678	Atu4683	Atu4678	Atu4683	ABC transporter, substrate binding protein (amino acid).	Conserved hypothetical protein.	0.815
Atu4678	Atu4684	Atu4678	Atu4684	ABC transporter, substrate binding protein (amino acid).	Conserved hypothetical protein; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4- hydroxy-D-proline (c4DHyp), albeit with 30-fold lower efficiency. Is likely involved in both degradation pathways that convert t3LHyp to L- proline and t4LHyp to alpha-ketoglutarate, which would allow A.tumefaciens to grow on t3LHyp or t4LHyp as a sole carbon source. Displays no proline racemase activity.	0.770
Atu4678	arcB	Atu4678	Atu3949	ABC transporter, substrate binding protein (amino acid).	Ornithine cyclodeaminase.	0.446
Atu4678	dadA-2	Atu4678	Atu4682	ABC transporter, substrate binding protein (amino acid).	D-amino acid dehydrogenase, small subunit.	0.880
Atu4678	dapA-6	Atu4678	Atu4675	ABC transporter, substrate binding protein (amino acid).	Dihydrodipicolinate synthase; Belongs to the DapA family.	0.721

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