A3770_03p27000 protein (Chloropicon primus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A3770_03p27000

AMP-dependent synthetase/ligase. (804 aa)

Predicted Functional Partners:

A3770_03p27070

0.969

A3770_03p26990

0.929

A3770_09p56720

0.897

A3770_08p53290

0.891

A3770_05p39900

0.886

A3770_08p53320

0.884

A3770_16p76460

0.884

A3770_03p26980

0.881

A3770_08p53310

0.858

A3770_08p53300

0.855

Your Current Organism:

Chloropicon primus

NCBI taxonomy Id: 1764295
Other names: C. primus, Chlorophyta sp. CCMP1205, Chloropicon primus Lopes dos Santos & Eikrem, 2017, Coccoid green alga CCMP1205, Prasino-clade-7_X-A2 sp. RCC717, Prasino-clade-7_X-A3 sp. RCC1019, Prasino-clade-7_X-A3 sp. RCC1032, Prasino-clade-7_X-A3 sp. RCC1043, Prasinophyceae sp. CCMP1205, Prasinophyceae sp. RCC1019 (clade 7X-A3), Prasinophyceae sp. RCC1032 (clade 7X-A3), Prasinophyceae sp. RCC1032 (clade VIIA), Prasinophyceae sp. RCC1043 (clade 7X-A3), Prasinophyceae sp. RCC717 (clade 7X-A2), coccoid chlorophyte sp. CCMP1205, coccoid prasinophyte sp. CCMP1205, prasinophyte sp. CCMP1205, prasinophyte sp. NIES-3671, prasinophyte sp. NIES-3671 (clade VIIA3), prasinophyte sp. RCC1019, prasinophyte sp. RCC1019 (clade VIIA3), prasinophyte sp. RCC1032, prasinophyte sp. RCC1032 (clade VIIA), prasinophyte sp. RCC1032 (clade VIIA3), prasinophyte sp. RCC1043, prasinophyte sp. RCC1043 (clade VIIA3), prasinophyte sp. RCC717, prasinophyte sp. RCC717 (clade VIIA2)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A3770_03p26980	A3770_03p26990	A0A5B8ML95	A0A5B8MIQ5	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_03p27000	A0A5B8ML95	A0A5B8MLB8	Polyketide synthase.	AMP-dependent synthetase/ligase.	0.881
A3770_03p26980	A3770_03p27070	A0A5B8ML95	A0A5B8MIH8	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_05p39900	A0A5B8ML95	A0A5B8MQ89	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_08p53290	A0A5B8ML95	A0A5B8MR10	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_08p53300	A0A5B8ML95	A0A5B8MTR0	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_08p53310	A0A5B8ML95	A0A5B8MQX5	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_08p53320	A0A5B8ML95	A0A5B8MSB9	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26980	A3770_09p56720	A0A5B8ML95	A0A5B8MTR6	Polyketide synthase.	Beta-ketoacyl synthase.	0.861
A3770_03p26980	A3770_16p76460	A0A5B8ML95	A0A5B8MXQ7	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_03p26980	A0A5B8MIQ5	A0A5B8ML95	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_03p27000	A0A5B8MIQ5	A0A5B8MLB8	Polyketide synthase.	AMP-dependent synthetase/ligase.	0.929
A3770_03p26990	A3770_03p27070	A0A5B8MIQ5	A0A5B8MIH8	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_05p39900	A0A5B8MIQ5	A0A5B8MQ89	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_08p53290	A0A5B8MIQ5	A0A5B8MR10	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_08p53300	A0A5B8MIQ5	A0A5B8MTR0	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_08p53310	A0A5B8MIQ5	A0A5B8MQX5	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_08p53320	A0A5B8MIQ5	A0A5B8MSB9	Polyketide synthase.	Polyketide synthase.	0.861
A3770_03p26990	A3770_09p56720	A0A5B8MIQ5	A0A5B8MTR6	Polyketide synthase.	Beta-ketoacyl synthase.	0.861
A3770_03p26990	A3770_16p76460	A0A5B8MIQ5	A0A5B8MXQ7	Polyketide synthase.	Polyketide synthase.	0.861

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

6 of 15

2.39

4.94

9.23e-11

GO:0000398

mRNA splicing, via spliceosome

11 of 121

1.75

4.53

3.49e-16

GO:0000244

Spliceosomal tri-snRNP complex assembly

2 of 5

2.39

1.16

0.0073

GO:0000393

Spliceosomal conformational changes to generate catalytic conformation

2 of 12

2.01

0.83

0.0270

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

4 of 17

2.16

2.49

1.11e-05

GO:0003723

RNA binding

11 of 531

1.11

1.51

1.17e-09

GO:0030623

U5 snRNA binding

2 of 5

2.39

1.03

0.0126

GO:0030620

U2 snRNA binding

2 of 7

2.25

0.94

0.0185

GO:0030619

U1 snRNA binding

2 of 7

2.25

0.94

0.0185

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005682

U5 snRNP

8 of 13

2.58

7.93

6.28e-17

GO:0097525

Spliceosomal snRNP complex

11 of 47

2.16

7.74

5.45e-21

GO:0005685

U1 snRNP

8 of 16

2.49

7.52

1.81e-16

GO:0046540

U4/U6 x U5 tri-snRNP complex

8 of 24

2.31

6.66

1.85e-15

GO:0071004

U2-type prespliceosome

7 of 20

2.33

5.94

2.05e-13

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5284

U4 snRNP, and Nuclear cap binding complex

8 of 10

2.69

8.52

1.00e-17

CL:5254

Spliceosomal snRNP complex, and Nuclear cap binding complex

11 of 41

2.22

8.18

2.14e-21

CL:5255

U2 snRNP, and Commitment complex

9 of 25

2.35

7.64

7.07e-18

CL:5287

U4 snRNP

5 of 5

2.79

5.26

1.20e-10

CL:5307

U5 snRNA binding, and Pre-mRNA-splicing factor Syf1-like

2 of 5

2.39

1.22

0.0056

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

11 of 117

1.76

4.83

9.98e-18

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72172

mRNA Splicing

11 of 98

1.84

5.25

1.01e-17

MAP-72163

mRNA Splicing - Major Pathway

10 of 88

1.84

4.9

1.24e-15

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 176

1.59

3.65

1.59e-15

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

4 of 6

2.61

3.62

1.44e-07

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

4 of 6

2.61

3.62

1.44e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005687

U4 snRNP

4 of 5

2.69

3.75

9.20e-08

GOCC:0097525

Spliceosomal snRNP complex

6 of 39

1.98

3.35

2.66e-08

GOCC:0005684

U2-type spliceosomal complex

6 of 43

1.93

3.28

2.66e-08

GOCC:0005682

U5 snRNP

4 of 11

2.35

3.18

6.20e-07

GOCC:0071004

U2-type prespliceosome

4 of 20

2.09

2.62

4.26e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

6 of 13

2.45

5.3

2.21e-11

KW-0747

Spliceosome

3 of 8

2.36

3.12e-05

KW-0687

Ribonucleoprotein

7 of 170

1.4

2.01

1.77e-07

KW-0694

RNA-binding

4 of 126

1.29

1.07

0.0015

KW-0539

Nucleus

6 of 332

1.05

0.97

0.00026

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001163

Sm domain, eukaryotic/archaea-type

7 of 16

2.43

5.73

1.81e-12

IPR047575

Sm domain

7 of 17

2.4

5.69

1.81e-12

IPR010920

LSM domain superfamily

7 of 19

2.36

5.6

1.81e-12

IPR027141

Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3

2 of 3

2.61

0.97

0.0176

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

7 of 16

2.43

6.15

1.92e-13

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