AKQ99863.1 protein (Mycobacterium tuberculosis variant bovis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AKQ99863.1

Antitoxin VapB2. (73 aa)

Predicted Functional Partners:

vapC-3

0.998

vapC-9

0.779

AKQ99862.1

0.733

AKQ99861.1

0.663

AKR00220.1

0.656

AKR00223.1

0.656

vapC-8

0.607

vapC-19

0.571

AKR01769.1

0.546

AKQ99865.1

0.523

Your Current Organism:

Mycobacterium tuberculosis variant bovis

NCBI taxonomy Id: 1765
Other names: ATCC 19210, CIP 105234, M. tuberculosis variant bovis, Mycobacterium bovis, Mycobacterium bovis subsp. bovis, Mycobacterium tuberculosis typus bovinus, Mycobacterium tuberculosis var. bovis, NCTC 10772

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKQ99861.1	AKQ99862.1	Mb1595_p0339	Mb1595_p0340	Antitoxin.	Toxin.	0.968
AKQ99861.1	AKQ99863.1	Mb1595_p0339	Mb1595_p0341	Antitoxin.	Antitoxin VapB2.	0.663
AKQ99861.1	AKQ99865.1	Mb1595_p0339	Mb1595_p0343	Antitoxin.	TetR/AcrR family transcriptional regulator.	0.424
AKQ99861.1	vapC-3	Mb1595_p0339	Mb1595_p0342	Antitoxin.	Ribonuclease VapC2; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.663
AKQ99862.1	AKQ99861.1	Mb1595_p0340	Mb1595_p0339	Toxin.	Antitoxin.	0.968
AKQ99862.1	AKQ99863.1	Mb1595_p0340	Mb1595_p0341	Toxin.	Antitoxin VapB2.	0.733
AKQ99862.1	AKQ99865.1	Mb1595_p0340	Mb1595_p0343	Toxin.	TetR/AcrR family transcriptional regulator.	0.424
AKQ99862.1	vapC-3	Mb1595_p0340	Mb1595_p0342	Toxin.	Ribonuclease VapC2; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.663
AKQ99863.1	AKQ99861.1	Mb1595_p0341	Mb1595_p0339	Antitoxin VapB2.	Antitoxin.	0.663
AKQ99863.1	AKQ99862.1	Mb1595_p0341	Mb1595_p0340	Antitoxin VapB2.	Toxin.	0.733
AKQ99863.1	AKQ99865.1	Mb1595_p0341	Mb1595_p0343	Antitoxin VapB2.	TetR/AcrR family transcriptional regulator.	0.523
AKQ99863.1	AKR00220.1	Mb1595_p0341	Mb1595_p0697	Antitoxin VapB2.	Antitoxin VapB30.	0.656
AKQ99863.1	AKR00223.1	Mb1595_p0341	Mb1595_p0700	Antitoxin VapB2.	Antitoxin VapB5; Antitoxin component of a type II toxin-antitoxin (TA) system.	0.656
AKQ99863.1	AKR01769.1	Mb1595_p0341	Mb1595_p2246	Antitoxin VapB2.	Antitoxin VapB15.	0.546
AKQ99863.1	vapC-19	Mb1595_p0341	Mb1595_p2247	Antitoxin VapB2.	Ribonuclease; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.571
AKQ99863.1	vapC-3	Mb1595_p0341	Mb1595_p0342	Antitoxin VapB2.	Ribonuclease VapC2; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.998
AKQ99863.1	vapC-8	Mb1595_p0341	Mb1595_p0698	Antitoxin VapB2.	Ribonuclease VapC; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.607
AKQ99863.1	vapC-9	Mb1595_p0341	Mb1595_p0701	Antitoxin VapB2.	Ribonuclease VapC5; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.	0.779
AKQ99865.1	AKQ99861.1	Mb1595_p0343	Mb1595_p0339	TetR/AcrR family transcriptional regulator.	Antitoxin.	0.424
AKQ99865.1	AKQ99862.1	Mb1595_p0343	Mb1595_p0340	TetR/AcrR family transcriptional regulator.	Toxin.	0.424

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.812

expected number of edges:

10

PPI enrichment p-value:

0.00965

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006542

Glutamine biosynthetic process

4 of 4

2.33

2.43

2.12e-05

GO:0042128

Nitrate assimilation

2 of 3

2.15

0.83

0.0294

GO:0043436

Oxoacid metabolic process

7 of 229

0.82

0.6

0.0050

GO:0044281

Small molecule metabolic process

8 of 394

0.64

0.44

0.0115

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004356

Glutamate-ammonia ligase activity

4 of 4

2.33

2.58

1.04e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2363

Nitrogen metabolism, and Rieske-like [2Fe-2S] domain

7 of 12

2.1

4.41

1.07e-10

CL:2376

Rieske-like [2Fe-2S] domain, and BFD-like [2Fe-2S] binding domain

4 of 5

2.23

2.86

2.12e-06

CL:2359

Mixed, incl. Nitrogen metabolism, and Porphyrin and chlorophyll metabolism

8 of 59

1.46

2.38

5.59e-09

CL:2358

Mixed, incl. Nitrogen metabolism, and Porphyrin and chlorophyll metabolism

9 of 87

1.35

2.13

1.88e-09

CL:2364

Ammonia ligase activity, and FAD binding domain

3 of 6

2.03

1.73

0.00037

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hna00910

Nitrogen metabolism

9 of 18

2.03

5.58

4.00e-15

hna00630

Glyoxylate and dicarboxylate metabolism

6 of 20

1.81

3.08

2.11e-08

hna00220

Arginine biosynthesis

4 of 17

1.7

1.96

2.90e-05

hna00250

Alanine, aspartate and glutamate metabolism

4 of 22

1.59

1.74

5.97e-05

hna01120

Microbial metabolism in diverse environments

9 of 140

1.14

1.52

2.11e-08

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13806

Rieske-like [2Fe-2S] domain

2 of 2

2.33

0.74

0.0445

PF04324

BFD-like [2Fe-2S] binding domain

2 of 2

2.33

0.74

0.0445

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036651

Glutamine synthetase, N-terminal domain superfamily

4 of 4

2.33

2.45

1.98e-05

IPR027303

Glutamine synthetase, glycine-rich site

4 of 4

2.33

2.45

1.98e-05

IPR008146

Glutamine synthetase, catalytic domain

4 of 4

2.33

2.45

1.98e-05

IPR014746

Glutamine synthetase/guanido kinase, catalytic domain

4 of 5

2.23

2.41

1.98e-05

IPR041854

BFD-like [2Fe-2S]-binding domain superfamily

2 of 2

2.33

0.86

0.0265

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01230

Glutamine synthetase, catalytic domain

4 of 4

2.33

2.93

1.96e-06

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