AKQ99880.1 protein (Mycobacterium tuberculosis variant bovis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

AKQ99880.1

Glycerophosphoryl diester phosphodiesterase GlpQ2. (256 aa)

Predicted Functional Partners:

AKR03781.1

0.966

AKR02060.1

0.965

AKQ99881.1

0.664

AKR03626.1

0.595

AKR02597.1

0.472

AKR02328.1

0.451

AKR02031.1

0.435

AKR03205.1

0.435

AKR00566.1

0.425

AKR00574.1

0.425

Your Current Organism:

Mycobacterium tuberculosis variant bovis

NCBI taxonomy Id: 1765
Other names: ATCC 19210, CIP 105234, M. tuberculosis variant bovis, Mycobacterium bovis, Mycobacterium bovis subsp. bovis, Mycobacterium tuberculosis typus bovinus, Mycobacterium tuberculosis var. bovis, NCTC 10772

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKQ99880.1	AKQ99881.1	Mb1595_p0358	Mb1595_p0359	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Hypothetical protein.	0.664
AKQ99880.1	AKR00566.1	Mb1595_p0358	Mb1595_p1043	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Phosphate-transport ABC transporter integral membrane protein PstA1.	0.425
AKQ99880.1	AKR00574.1	Mb1595_p0358	Mb1595_p1051	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Phosphate-transport ABC transporter integral membrane protein PstA2.	0.425
AKQ99880.1	AKR02031.1	Mb1595_p0358	Mb1595_p2508	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Glycerol-3-phosphate dehydrogenase 1; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.435
AKQ99880.1	AKR02060.1	Mb1595_p0358	Mb1595_p2537	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Glycerolphosphodiesterase.	0.965
AKQ99880.1	AKR02328.1	Mb1595_p0358	Mb1595_p2805	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Membrane protein.	0.451
AKQ99880.1	AKR02597.1	Mb1595_p0358	Mb1595_p3074	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.472
AKQ99880.1	AKR03205.1	Mb1595_p0358	Mb1595_p3682	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Glycerol-3-phosphate dehydrogenase 2; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.435
AKQ99880.1	AKR03626.1	Mb1595_p0358	Mb1595_p4103	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Glycerol kinase.	0.595
AKQ99880.1	AKR03781.1	Mb1595_p0358	Mb1595_p4258	Glycerophosphoryl diester phosphodiesterase GlpQ2.	Glycerophosphoryl diester phosphodiesterase.	0.966
AKQ99881.1	AKQ99880.1	Mb1595_p0359	Mb1595_p0358	Hypothetical protein.	Glycerophosphoryl diester phosphodiesterase GlpQ2.	0.664
AKR00566.1	AKQ99880.1	Mb1595_p1043	Mb1595_p0358	Phosphate-transport ABC transporter integral membrane protein PstA1.	Glycerophosphoryl diester phosphodiesterase GlpQ2.	0.425
AKR00566.1	AKR00574.1	Mb1595_p1043	Mb1595_p1051	Phosphate-transport ABC transporter integral membrane protein PstA1.	Phosphate-transport ABC transporter integral membrane protein PstA2.	0.927
AKR00566.1	AKR02060.1	Mb1595_p1043	Mb1595_p2537	Phosphate-transport ABC transporter integral membrane protein PstA1.	Glycerolphosphodiesterase.	0.425
AKR00566.1	AKR03781.1	Mb1595_p1043	Mb1595_p4258	Phosphate-transport ABC transporter integral membrane protein PstA1.	Glycerophosphoryl diester phosphodiesterase.	0.425
AKR00574.1	AKQ99880.1	Mb1595_p1051	Mb1595_p0358	Phosphate-transport ABC transporter integral membrane protein PstA2.	Glycerophosphoryl diester phosphodiesterase GlpQ2.	0.425
AKR00574.1	AKR00566.1	Mb1595_p1051	Mb1595_p1043	Phosphate-transport ABC transporter integral membrane protein PstA2.	Phosphate-transport ABC transporter integral membrane protein PstA1.	0.927
AKR00574.1	AKR02060.1	Mb1595_p1051	Mb1595_p2537	Phosphate-transport ABC transporter integral membrane protein PstA2.	Glycerolphosphodiesterase.	0.425
AKR00574.1	AKR03781.1	Mb1595_p1051	Mb1595_p4258	Phosphate-transport ABC transporter integral membrane protein PstA2.	Glycerophosphoryl diester phosphodiesterase.	0.425
AKR02031.1	AKQ99880.1	Mb1595_p2508	Mb1595_p0358	Glycerol-3-phosphate dehydrogenase 1; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	Glycerophosphoryl diester phosphodiesterase GlpQ2.	0.435

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.881

expected number of edges:

15

PPI enrichment p-value:

6.79e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051276

Chromosome organization

5 of 26

1.86

2.37

5.40e-06

GO:0071103

DNA conformation change

4 of 17

1.95

2.05

5.67e-05

GO:0006281

DNA repair

5 of 51

1.57

1.72

5.67e-05

GO:0006259

DNA metabolic process

8 of 178

1.23

1.49

3.02e-06

GO:0006260

DNA replication

3 of 36

1.5

0.95

0.0083

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008094

ATP-dependent activity, acting on DNA

6 of 21

2.03

3.7

4.95e-09

GO:0140097

Catalytic activity, acting on DNA

10 of 107

1.55

3.13

1.83e-12

GO:0003678

DNA helicase activity

3 of 8

2.15

1.85

0.00025

GO:0003887

DNA-directed DNA polymerase activity

3 of 11

2.01

1.67

0.00049

GO:0140664

ATP-dependent DNA damage sensor activity

2 of 4

2.27

1.21

0.0057

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009360

DNA polymerase III complex

2 of 5

2.18

0.95

0.0170

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:599

Mixed, incl. Mismatched DNA binding, and DNA helicase activity

6 of 7

2.51

5.44

1.54e-11

CL:595

DNA repair, and Primosome

8 of 25

2.08

5.21

3.03e-13

CL:596

DNA repair, and DNA helicase activity

7 of 18

2.16

5.0

6.03e-12

CL:593

DNA repair, and DNA-directed DNA polymerase activity

9 of 41

1.92

4.75

1.32e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

6 of 27

1.92

3.41

9.30e-09

map03440

Homologous recombination

5 of 30

1.8

2.56

9.32e-07

map03420

Nucleotide excision repair

3 of 13

1.94

1.72

0.00033

map03030

DNA replication

3 of 35

1.51

1.09

0.0037

map03410

Base excision repair

2 of 22

1.53

0.67

0.0449

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 5

2.35

1.91

0.00025

GOCC:0044815

DNA packaging complex

3 of 11

2.01

1.65

0.00053

GOCC:0009360

DNA polymerase III complex

2 of 6

2.1

0.98

0.0142

GOCC:1902494

Catalytic complex

5 of 245

0.88

0.58

0.0142

GOCC:0005622

Intracellular

10 of 1593

0.37

0.28

0.0241

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 12

1.97

1.45

0.0014

KW-0234

DNA repair

3 of 28

1.6

1.1

0.0044

KW-0548

Nucleotidyltransferase

3 of 32

1.55

1.08

0.0044

KW-0239

DNA-directed DNA polymerase

2 of 8

1.97

1.04

0.0104

KW-0238

DNA-binding

6 of 209

1.03

0.85

0.0014

(more ...)

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