AKR00596.1 protein (Mycobacterium tuberculosis variant bovis)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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[Homology]

Score

AKR00596.1

Membrane protein. (455 aa)

Predicted Functional Partners:

AKR03529.1

0.773

AKR00842.1

0.765

purN

0.763

AKR00598.1

0.763

AKQ99792.1

0.757

AKQ99579.1

0.727

AKR02514.1

0.725

AKR02513.1

0.715

AKR00599.1

0.694

AKR00600.1

0.694

Your Current Organism:

Mycobacterium tuberculosis variant bovis

NCBI taxonomy Id: 1765
Other names: ATCC 19210, CIP 105234, M. tuberculosis variant bovis, Mycobacterium bovis, Mycobacterium bovis subsp. bovis, Mycobacterium tuberculosis typus bovinus, Mycobacterium tuberculosis var. bovis, NCTC 10772

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKQ99579.1	AKQ99792.1	Mb1595_p0057	Mb1595_p0270	Membrane protein.	Arabinofuranosyltransferase AftD.	0.564
AKQ99579.1	AKR00596.1	Mb1595_p0057	Mb1595_p1073	Membrane protein.	Membrane protein.	0.727
AKQ99579.1	AKR00842.1	Mb1595_p0057	Mb1595_p1319	Membrane protein.	Mannosyltransferase.	0.762
AKQ99579.1	AKR03529.1	Mb1595_p0057	Mb1595_p4006	Membrane protein.	Membrane protein.	0.737
AKQ99792.1	AKQ99579.1	Mb1595_p0270	Mb1595_p0057	Arabinofuranosyltransferase AftD.	Membrane protein.	0.564
AKQ99792.1	AKR00596.1	Mb1595_p0270	Mb1595_p1073	Arabinofuranosyltransferase AftD.	Membrane protein.	0.757
AKQ99792.1	AKR00842.1	Mb1595_p0270	Mb1595_p1319	Arabinofuranosyltransferase AftD.	Mannosyltransferase.	0.787
AKQ99792.1	AKR03529.1	Mb1595_p0270	Mb1595_p4006	Arabinofuranosyltransferase AftD.	Membrane protein.	0.551
AKR00596.1	AKQ99579.1	Mb1595_p1073	Mb1595_p0057	Membrane protein.	Membrane protein.	0.727
AKR00596.1	AKQ99792.1	Mb1595_p1073	Mb1595_p0270	Membrane protein.	Arabinofuranosyltransferase AftD.	0.757
AKR00596.1	AKR00598.1	Mb1595_p1073	Mb1595_p1075	Membrane protein.	Bifunctional purine biosynthesis protein PurH.	0.763
AKR00596.1	AKR00599.1	Mb1595_p1073	Mb1595_p1076	Membrane protein.	Magnesium chelatase.	0.694
AKR00596.1	AKR00600.1	Mb1595_p1073	Mb1595_p1077	Membrane protein.	Hypothetical protein.	0.694
AKR00596.1	AKR00842.1	Mb1595_p1073	Mb1595_p1319	Membrane protein.	Mannosyltransferase.	0.765
AKR00596.1	AKR02513.1	Mb1595_p1073	Mb1595_p2990	Membrane protein.	Fluoroquinolones export permease.	0.715
AKR00596.1	AKR02514.1	Mb1595_p1073	Mb1595_p2991	Membrane protein.	Fluoroquinolones export permease.	0.725
AKR00596.1	AKR03529.1	Mb1595_p1073	Mb1595_p4006	Membrane protein.	Membrane protein.	0.773
AKR00596.1	purN	Mb1595_p1073	Mb1595_p1074	Membrane protein.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.763
AKR00598.1	AKR00596.1	Mb1595_p1075	Mb1595_p1073	Bifunctional purine biosynthesis protein PurH.	Membrane protein.	0.763
AKR00598.1	AKR00599.1	Mb1595_p1075	Mb1595_p1076	Bifunctional purine biosynthesis protein PurH.	Magnesium chelatase.	0.767

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.836

expected number of edges:

11

PPI enrichment p-value:

0.0161

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006629

Lipid metabolic process

8 of 1176

1.32

1.65

2.82e-06

GO:0044255

Cellular lipid metabolic process

6 of 880

1.32

1.22

0.00044

GO:0006490

Oligosaccharide-lipid intermediate biosynthetic process

2 of 14

2.64

1.03

0.0132

GO:0034645

Cellular macromolecule biosynthetic process

5 of 834

1.26

0.9

0.0052

GO:0044242

Cellular lipid catabolic process

3 of 198

1.66

0.79

0.0268

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016758

Hexosyltransferase activity

6 of 233

1.89

2.96

1.50e-07

GO:0004376

Glycolipid mannosyltransferase activity

2 of 7

2.94

1.38

0.0032

GO:0004373

Glycogen (starch) synthase activity

2 of 7

2.94

1.38

0.0032

GO:0008194

UDP-glycosyltransferase activity

3 of 180

1.71

0.99

0.0099

GO:0016790

Thiolester hydrolase activity

2 of 49

2.09

0.81

0.0304

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005782

Peroxisomal matrix

2 of 20

2.48

0.91

0.0223

GO:0005737

Cytoplasm

11 of 12389

0.43

0.31

0.0223

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28161

Thiolase, C-terminal domain, and delta(3)-delta(2)-enoyl-CoA isomerase activity

3 of 6

3.18

2.74

1.09e-05

CL:33443

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, and Glycosyl transferase, family 1

2 of 5

3.09

1.7

0.00085

CL:33352

GPI anchor metabolic process, and Oligosaccharide-lipid intermediate biosynthetic process

3 of 58

2.2

1.69

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01040

Biosynthesis of unsaturated fatty acids

4 of 62

2.29

3.2

4.55e-07

map04146

Peroxisome

4 of 178

1.84

2.16

1.83e-05

map00120

Primary bile acid biosynthesis

2 of 14

2.64

1.81

0.00048

map01212

Fatty acid metabolism

3 of 124

1.87

1.63

0.00044

map00513

Various types of N-glycan biosynthesis

2 of 59

2.01

1.16

0.0060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

4 of 21

2.76

3.7

1.27e-07

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

4 of 21

2.76

3.7

1.27e-07

MAP-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

4 of 23

2.72

3.69

1.27e-07

MAP-389887

Beta-oxidation of pristanoyl-CoA

4 of 25

2.69

3.68

1.27e-07

MAP-192105

Synthesis of bile acids and bile salts

4 of 35

2.54

3.56

1.65e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 128

1.98

1.93

0.00012

GOCC:0005782

Peroxisomal matrix

2 of 21

2.46

1.03

0.0128

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0320

Glycogen biosynthesis

2 of 5

3.09

1.77

0.00064

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13692

Glycosyl transferases group 1

3 of 5

3.26

3.01

3.61e-06

PF02803

Thiolase, C-terminal domain

3 of 10

2.96

2.76

9.22e-06

PF05693

Glycogen synthase

2 of 5

3.09

1.53

0.0017

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001296

Glycosyl transferase, family 1

3 of 8

3.06

2.48

3.12e-05

IPR016039

Thiolase-like

3 of 22

2.62

1.98

0.00022

IPR008631

Glycogen synthase

2 of 5

3.09

1.28

0.0049

IPR020617

Thiolase, C-terminal

2 of 9

2.83

1.11

0.0097

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