AKR03582.1 protein (Mycobacterium tuberculosis variant bovis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AKR03582.1

Alanine rich membrane protein. (191 aa)

Predicted Functional Partners:

AKR03584.1

0.975

AKR03585.1

0.968

AKR03581.1

0.955

AKR03583.1

0.910

AKR03580.1

0.885

AKR00635.1

0.769

AKR03579.1

0.707

AKR03131.1

0.704

AKR01945.1

0.662

AKR03366.1

0.662

Your Current Organism:

Mycobacterium tuberculosis variant bovis

NCBI taxonomy Id: 1765
Other names: ATCC 19210, CIP 105234, M. tuberculosis variant bovis, Mycobacterium bovis, Mycobacterium bovis subsp. bovis, Mycobacterium tuberculosis typus bovinus, Mycobacterium tuberculosis var. bovis, NCTC 10772

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR00635.1	AKR03580.1	Mb1595_p1112	Mb1595_p4057	Hypothetical protein.	Hypothetical protein.	0.715
AKR00635.1	AKR03582.1	Mb1595_p1112	Mb1595_p4059	Hypothetical protein.	Alanine rich membrane protein.	0.769
AKR00635.1	AKR03583.1	Mb1595_p1112	Mb1595_p4060	Hypothetical protein.	Transmembrane protein.	0.789
AKR00635.1	AKR03584.1	Mb1595_p1112	Mb1595_p4061	Hypothetical protein.	General secretion pathway protein GspE.	0.554
AKR00635.1	AKR03585.1	Mb1595_p1112	Mb1595_p4062	Hypothetical protein.	Hypothetical protein.	0.753
AKR01945.1	AKR03131.1	Mb1595_p2422	Mb1595_p3608	Acetyltransferase.	Hypothetical protein.	0.772
AKR01945.1	AKR03581.1	Mb1595_p2422	Mb1595_p4058	Acetyltransferase.	Hypothetical protein.	0.446
AKR01945.1	AKR03582.1	Mb1595_p2422	Mb1595_p4059	Acetyltransferase.	Alanine rich membrane protein.	0.662
AKR03131.1	AKR01945.1	Mb1595_p3608	Mb1595_p2422	Hypothetical protein.	Acetyltransferase.	0.772
AKR03131.1	AKR03366.1	Mb1595_p3608	Mb1595_p3843	Hypothetical protein.	ESX-4 secretion system protein EccB4.	0.539
AKR03131.1	AKR03581.1	Mb1595_p3608	Mb1595_p4058	Hypothetical protein.	Hypothetical protein.	0.518
AKR03131.1	AKR03582.1	Mb1595_p3608	Mb1595_p4059	Hypothetical protein.	Alanine rich membrane protein.	0.704
AKR03366.1	AKR03131.1	Mb1595_p3843	Mb1595_p3608	ESX-4 secretion system protein EccB4.	Hypothetical protein.	0.539
AKR03366.1	AKR03582.1	Mb1595_p3843	Mb1595_p4059	ESX-4 secretion system protein EccB4.	Alanine rich membrane protein.	0.662
AKR03579.1	AKR03580.1	Mb1595_p4056	Mb1595_p4057	Helicase.	Hypothetical protein.	0.770
AKR03579.1	AKR03581.1	Mb1595_p4056	Mb1595_p4058	Helicase.	Hypothetical protein.	0.715
AKR03579.1	AKR03582.1	Mb1595_p4056	Mb1595_p4059	Helicase.	Alanine rich membrane protein.	0.707
AKR03579.1	AKR03583.1	Mb1595_p4056	Mb1595_p4060	Helicase.	Transmembrane protein.	0.656
AKR03579.1	AKR03584.1	Mb1595_p4056	Mb1595_p4061	Helicase.	General secretion pathway protein GspE.	0.666
AKR03579.1	AKR03585.1	Mb1595_p4056	Mb1595_p4062	Helicase.	Hypothetical protein.	0.648

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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