STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (164 aa)    
Predicted Functional Partners:
ruvA
Holliday junction branch migration protein RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 0.999
ruvB
Holliday junction branch migration DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.993
APZ43387.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.955
APZ43383.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.808
aspS
aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
      0.797
APZ43381.1
Two-component system response regulator GlrR; With GlrK is part of a two-component signal transduction system regulating glmY; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.789
APZ43382.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.773
APZ43389.1
Dihydroneopterin triphosphate diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.645
recX
Hypothetical protein; Modulates RecA activity; Belongs to the RecX family.
   
  
 0.588
APZ43388.1
Acetyltransferase/hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.532
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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