node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALI25333.1 | ALI26193.1 | XA26_14860 | XA26_23480 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.929 |
ALI25333.1 | ALI26967.1 | XA26_14860 | XA26_31350 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase. | 0.967 |
ALI25333.1 | ALI27682.1 | XA26_14860 | XA26_38650 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Acetohydroxy acid synthase; Belongs to the TPP enzyme family. | 0.926 |
ALI25333.1 | ilvA | XA26_14860 | XA26_30020 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.943 |
ALI25333.1 | ilvC | XA26_14860 | XA26_23500 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.989 |
ALI25333.1 | ilvD | XA26_14860 | XA26_01780 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.842 |
ALI25333.1 | ilvN | XA26_14860 | XA26_23490 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.994 |
ALI25333.1 | leuA | XA26_14860 | XA26_30430 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.930 |
ALI25333.1 | leuA-2 | XA26_14860 | XA26_56450 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.930 |
ALI25333.1 | leuB_1 | XA26_14860 | XA26_23560 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.966 |
ALI26193.1 | ALI25333.1 | XA26_23480 | XA26_14860 | Acetolactate synthase large subunit. | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 0.929 |
ALI26193.1 | ALI26967.1 | XA26_23480 | XA26_31350 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase. | 0.972 |
ALI26193.1 | ALI27682.1 | XA26_23480 | XA26_38650 | Acetolactate synthase large subunit. | Acetohydroxy acid synthase; Belongs to the TPP enzyme family. | 0.925 |
ALI26193.1 | ilvA | XA26_23480 | XA26_30020 | Acetolactate synthase large subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.959 |
ALI26193.1 | ilvC | XA26_23480 | XA26_23500 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
ALI26193.1 | ilvD | XA26_23480 | XA26_01780 | Acetolactate synthase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.927 |
ALI26193.1 | ilvN | XA26_23480 | XA26_23490 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
ALI26193.1 | leuA | XA26_23480 | XA26_30430 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.939 |
ALI26193.1 | leuA-2 | XA26_23480 | XA26_56450 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.982 |
ALI26193.1 | leuB_1 | XA26_23480 | XA26_23560 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.980 |