STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (683 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.987
ALI25027.1
Ribosylnicotinamide kinase.
    
 0.986
ppnK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.953
cobB-3
NAD-dependent protein deacetylase of SIR2 family; Belongs to the sirtuin family. Class III subfamily.
   
 0.944
sthA
Soluble pyridine nucleotide transhydrogenase.
    
 0.929
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.926
ALI25797.1
NADH pyrophosphatase.
  
 
 0.915
ALI23970.1
NAD(P) transhydrogenase alpha subunit.
     
 0.910
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
 
 0.885
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
   
 
 0.845
Your Current Organism:
Mycolicibacterium fortuitum
NCBI taxonomy Id: 1766
Other names: ATCC 6841, CCUG 20994, CIP 104534, DSM 46621, IFO 13159, JCM 6387, M. fortuitum, Mycobacterium fortuitum, Mycobacterium giae, Mycobacterium minetti, NBRC 13159, NCTC 10394
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