ALI28057.1 protein (Mycolicibacterium fortuitum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

ALI28057.1

NADPH-dependent FMN reductase family protein. (193 aa)

Predicted Functional Partners:

ALI26404.1

0.935

rutA_4

0.935

cysH

0.925

ALI27477.1

0.919

ribF

0.910

sir

0.910

ALI29167.1

0.909

ALI24905.1

0.906

ALI25537.1

0.906

sseA_1

0.906

Your Current Organism:

Mycolicibacterium fortuitum

NCBI taxonomy Id: 1766
Other names: ATCC 6841, CCUG 20994, CIP 104534, DSM 46621, IFO 13159, JCM 6387, M. fortuitum, Mycobacterium fortuitum, Mycobacterium giae, Mycobacterium minetti, NBRC 13159, NCTC 10394

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALI24905.1	ALI25537.1	XA26_10480	XA26_16900	Thiosulfate sulfurtransferase, rhodanese.	NADPH-dependent FMN reductase family protein.	0.906
ALI24905.1	ALI26404.1	XA26_10480	XA26_25610	Thiosulfate sulfurtransferase, rhodanese.	Alkanesulfonate monooxygenase.	0.900
ALI24905.1	ALI27477.1	XA26_10480	XA26_36560	Thiosulfate sulfurtransferase, rhodanese.	Assimilatory nitrate reductase large subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.	0.937
ALI24905.1	ALI28057.1	XA26_10480	XA26_42520	Thiosulfate sulfurtransferase, rhodanese.	NADPH-dependent FMN reductase family protein.	0.906
ALI24905.1	cysH	XA26_10480	XA26_39350	Thiosulfate sulfurtransferase, rhodanese.	Phosphoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.	0.910
ALI24905.1	sir	XA26_10480	XA26_39340	Thiosulfate sulfurtransferase, rhodanese.	Ferredoxin--sulfite reductase, actinobacterial type; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	0.914
ALI24905.1	sseA_1	XA26_10480	XA26_18390	Thiosulfate sulfurtransferase, rhodanese.	Thiosulfate sulfurtransferase, rhodanese.	0.905
ALI25537.1	ALI24905.1	XA26_16900	XA26_10480	NADPH-dependent FMN reductase family protein.	Thiosulfate sulfurtransferase, rhodanese.	0.906
ALI25537.1	ALI26404.1	XA26_16900	XA26_25610	NADPH-dependent FMN reductase family protein.	Alkanesulfonate monooxygenase.	0.935
ALI25537.1	ALI27477.1	XA26_16900	XA26_36560	NADPH-dependent FMN reductase family protein.	Assimilatory nitrate reductase large subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.	0.923
ALI25537.1	ALI28057.1	XA26_16900	XA26_42520	NADPH-dependent FMN reductase family protein.	NADPH-dependent FMN reductase family protein.	0.906
ALI25537.1	ALI29167.1	XA26_16900	XA26_53750	NADPH-dependent FMN reductase family protein.	Cobalamin biosynthesis protein BluB; 5,6-dimethylbenzimidazole synthase, flavin destructase family.	0.909
ALI25537.1	cysH	XA26_16900	XA26_39350	NADPH-dependent FMN reductase family protein.	Phosphoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.	0.925
ALI25537.1	ribF	XA26_16900	XA26_25630	NADPH-dependent FMN reductase family protein.	Riboflavin kinase; FMN adenylyltransferase; Belongs to the ribF family.	0.910
ALI25537.1	rutA_4	XA26_16900	XA26_49500	NADPH-dependent FMN reductase family protein.	Flavin-dependent oxidoreductase; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related; sulfonate monooxygenase.	0.935
ALI25537.1	sir	XA26_16900	XA26_39340	NADPH-dependent FMN reductase family protein.	Ferredoxin--sulfite reductase, actinobacterial type; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	0.910
ALI25537.1	sseA_1	XA26_16900	XA26_18390	NADPH-dependent FMN reductase family protein.	Thiosulfate sulfurtransferase, rhodanese.	0.906
ALI26404.1	ALI24905.1	XA26_25610	XA26_10480	Alkanesulfonate monooxygenase.	Thiosulfate sulfurtransferase, rhodanese.	0.900
ALI26404.1	ALI25537.1	XA26_25610	XA26_16900	Alkanesulfonate monooxygenase.	NADPH-dependent FMN reductase family protein.	0.935
ALI26404.1	ALI27477.1	XA26_25610	XA26_36560	Alkanesulfonate monooxygenase.	Assimilatory nitrate reductase large subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.	0.908

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.542

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006891

intra-Golgi vesicle-mediated transport

9 of 77

2.62

9.15

1.57e-19

GO:0006888

Endoplasmic reticulum to Golgi vesicle-mediated transport

9 of 179

2.26

6.94

8.64e-17

GO:0048193

Golgi vesicle transport

11 of 352

2.05

6.77

1.57e-19

GO:0006890

Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

7 of 89

2.45

6.38

6.67e-14

GO:0006886

Intracellular protein transport

9 of 801

1.6

3.24

9.36e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005198

Structural molecule activity

7 of 884

1.45

1.91

2.08e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030126

COPI vesicle coat

11 of 47

2.92

14.38

2.20e-29

GO:0000139

Golgi membrane

11 of 758

1.72

4.58

9.62e-18

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30333

COPI-coated vesicle membrane

11 of 26

3.18

15.81

6.65e-31

CL:30335

COPI vesicle coat

10 of 19

3.28

14.9

1.02e-28

CL:30336

COPI-coated vesicle membrane

6 of 12

3.25

8.2

8.14e-16

CL:30361

Mixed, incl. Coatomer delta subunit, and Coatomer, alpha subunit, C-terminal

4 of 5

3.46

5.36

1.91e-10

CL:30350

Mixed, incl. Coatomer beta C-terminal region, and Coatomer subunit gamma, C-terminal

3 of 5

3.33

3.54

3.91e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6807878

COPI-mediated anterograde transport

11 of 210

2.27

8.85

1.12e-22

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

11 of 211

2.27

8.84

1.12e-22

MAP-8856688

Golgi-to-ER retrograde transport

11 of 248

2.2

8.35

2.23e-22

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

11 of 312

2.1

7.51

1.98e-21

MAP-199977

ER to Golgi Anterograde Transport

11 of 316

2.1

7.48

1.98e-21

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030126

COPI vesicle coat

11 of 19

3.32

17.03

8.85e-33

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0931

ER-Golgi transport

8 of 39

2.87

9.72

1.28e-19

KW-0968

Cytoplasmic vesicle

7 of 49

2.71

7.79

4.63e-16

KW-0333

Golgi apparatus

8 of 162

2.25

6.45

1.96e-15

KW-0653

Protein transport

8 of 201

2.15

5.94

7.91e-15

KW-0963

Cytoplasm

8 of 396

1.86

4.31

1.30e-12

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04053

Coatomer WD associated region

3 of 14

2.88

2.5

2.67e-05

PF14806

Coatomer beta subunit appendage platform

2 of 3

3.38

1.7

0.00086

PF07718

Coatomer beta C-terminal region

2 of 3

3.38

1.7

0.00086

PF06957

Coatomer (COPI) alpha subunit C-terminus

2 of 3

3.38

1.7

0.00086

PF00928

Adaptor complexes medium subunit family

2 of 13

2.74

1.34

0.0036

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047312

Coatomer subunit alpha, WD Associated Region

3 of 3

3.55

3.13

2.26e-06

IPR016460

Coatomer beta subunit (COPB1)

3 of 5

3.33

3.04

3.17e-06

IPR011012

Longin-like domain superfamily

4 of 55

2.42

2.85

3.46e-06

IPR006692

Coatomer, WD associated region

3 of 17

2.8

2.45

3.22e-05

IPR002553

Clathrin/coatomer adaptor, adaptin-like, N-terminal

3 of 26

2.62

2.21

8.25e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

3 of 324

1.52

0.65

0.0495

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