ALI28235.1 protein (Mycolicibacterium fortuitum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ALI28235.1

Two-component system response regulator. (249 aa)

Predicted Functional Partners:

ALI28236.1

0.979

ALI29011.1

0.927

ALI24835.1

0.917

ALI24062.1

0.899

ALI25062.1

0.887

ALI26548.1

0.885

tcrY_2

0.885

ALI28198.1

0.881

ALI28712.1

0.881

ALI29122.1

0.880

Your Current Organism:

Mycolicibacterium fortuitum

NCBI taxonomy Id: 1766
Other names: ATCC 6841, CCUG 20994, CIP 104534, DSM 46621, IFO 13159, JCM 6387, M. fortuitum, Mycobacterium fortuitum, Mycobacterium giae, Mycobacterium minetti, NBRC 13159, NCTC 10394

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALI24062.1	ALI24835.1	XA26_01960	XA26_09760	Sensor histidine kinase.	PhoR-like protein.	0.476
ALI24062.1	ALI25062.1	XA26_01960	XA26_12090	Sensor histidine kinase.	Sensor-type histidine kinase prrB.	0.912
ALI24062.1	ALI26548.1	XA26_01960	XA26_27070	Sensor histidine kinase.	Sensor histidine kinase.	0.916
ALI24062.1	ALI28235.1	XA26_01960	XA26_44350	Sensor histidine kinase.	Two-component system response regulator.	0.899
ALI24062.1	ALI28712.1	XA26_01960	XA26_49170	Sensor histidine kinase.	Osmosensitive K+ channel histidine kinase KdpD.	0.478
ALI24062.1	ALI29011.1	XA26_01960	XA26_52170	Sensor histidine kinase.	PhoR-like protein.	0.485
ALI24835.1	ALI24062.1	XA26_09760	XA26_01960	PhoR-like protein.	Sensor histidine kinase.	0.476
ALI24835.1	ALI25062.1	XA26_09760	XA26_12090	PhoR-like protein.	Sensor-type histidine kinase prrB.	0.477
ALI24835.1	ALI26548.1	XA26_09760	XA26_27070	PhoR-like protein.	Sensor histidine kinase.	0.479
ALI24835.1	ALI28198.1	XA26_09760	XA26_43980	PhoR-like protein.	Sensor histidine kinase.	0.424
ALI24835.1	ALI28235.1	XA26_09760	XA26_44350	PhoR-like protein.	Two-component system response regulator.	0.917
ALI24835.1	ALI28236.1	XA26_09760	XA26_44360	PhoR-like protein.	Osmosensitive K+ channel histidine kinase KdpD.	0.451
ALI24835.1	ALI28712.1	XA26_09760	XA26_49170	PhoR-like protein.	Osmosensitive K+ channel histidine kinase KdpD.	0.451
ALI24835.1	ALI29122.1	XA26_09760	XA26_53300	PhoR-like protein.	Putative two-component system sensor kinase.	0.438
ALI24835.1	tcrY_2	XA26_09760	XA26_51020	PhoR-like protein.	Two-component system, sensor protein.	0.429
ALI25062.1	ALI24062.1	XA26_12090	XA26_01960	Sensor-type histidine kinase prrB.	Sensor histidine kinase.	0.912
ALI25062.1	ALI24835.1	XA26_12090	XA26_09760	Sensor-type histidine kinase prrB.	PhoR-like protein.	0.477
ALI25062.1	ALI26548.1	XA26_12090	XA26_27070	Sensor-type histidine kinase prrB.	Sensor histidine kinase.	0.903
ALI25062.1	ALI28235.1	XA26_12090	XA26_44350	Sensor-type histidine kinase prrB.	Two-component system response regulator.	0.887
ALI25062.1	ALI28712.1	XA26_12090	XA26_49170	Sensor-type histidine kinase prrB.	Osmosensitive K+ channel histidine kinase KdpD.	0.478

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

15

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006098

Pentose-phosphate shunt

4 of 11

1.93

0.00010

GO:0046365

Monosaccharide catabolic process

4 of 18

1.71

1.7

0.00017

GO:0005996

Monosaccharide metabolic process

5 of 39

1.47

1.55

0.00010

GO:0019323

Pentose catabolic process

3 of 8

1.94

1.49

0.0011

GO:0044282

Small molecule catabolic process

6 of 60

1.37

1.43

0.00010

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:877

NADPH regeneration, and Gluconate transporter

6 of 8

2.24

4.18

1.95e-09

CL:757

Carbon metabolism, and Pyruvate metabolism

7 of 68

1.38

1.83

1.16e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

thl00040

Pentose and glucuronate interconversions

4 of 12

1.89

2.31

9.85e-06

thl00030

Pentose phosphate pathway

5 of 27

1.63

2.12

4.35e-06

thl01120

Microbial metabolism in diverse environments

8 of 123

1.18

1.49

4.94e-07

thl01200

Carbon metabolism

5 of 65

1.25

1.27

0.00012

thl00480

Glutathione metabolism

2 of 8

1.76

1.01

0.0096

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005856

Cytoskeleton

3 of 20

1.54

0.79

0.0236

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036409

Class II aldolase/adducin N-terminal domain superfamily

3 of 3

2.37

1.57

0.0012

IPR001303

Class II aldolase/adducin N-terminal

3 of 3

2.37

1.57

0.0012

IPR006183

6-phosphogluconate dehydrogenase

2 of 2

2.37

0.79

0.0354

IPR006114

6-phosphogluconate dehydrogenase, C-terminal

2 of 2

2.37

0.79

0.0354

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01007

Class II Aldolase and Adducin N-terminal domain

3 of 3

2.37

2.07

0.00012

SM01350

6-phosphogluconate dehydrogenase, C-terminal domain

2 of 2

2.37

1.23

0.0052

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