STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCSuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)    
Predicted Functional Partners:
sucD
Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
kgd
Multifunctional 2-oxoglutarate metabolism enzyme.
 
 0.999
aceF
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.
 
 0.993
sdhB
Succinate dehydrogenase iron-sulfur subunit.
 
 0.988
AMO63898.1
Hypothetical protein.
  
 0.988
sdhA_1
Succinate dehydrogenase flavoprotein subunit.
 
 0.984
AMO60335.1
Succinate dehydrogenase/Fumarate reductase transmembrane subunit.
  
 
 0.983
AMO60334.1
Succinate dehydrogenase/Fumarate reductase transmembrane subunit.
  
 
 0.982
frdB
Fumarate reductase iron-sulfur subunit.
 
 0.981
bkdC
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex.
  
 0.979
Your Current Organism:
Mycolicibacterium phlei
NCBI taxonomy Id: 1771
Other names: ATCC 11758, Bacterium phlei, CCUG 21000, CIP 105389, DSM 43239, JCM 5865, JCM 6385, M. phlei, Mycobacterium phlei, NCTC 8151, NRRL B-14615, Sclerothrix phlei
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.