STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (228 aa)    
Predicted Functional Partners:
thiL_2
Thiamine-monophosphate kinase.
  
    0.813
xthA_1
Exodeoxyribonuclease III.
  
 0.807
exoA
Exodeoxyribonuclease.
  
 0.807
xthA_2
Exodeoxyribonuclease III.
  
 0.807
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.724
pdg
Ultraviolet N-glycosylase/AP lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.612
polA_2
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.588
pepN_2
Aminopeptidase N.
 
   
 0.586
AMO60886.1
Hypothetical protein.
       0.579
end
Putative endonuclease 4.
   
 
 0.543
Your Current Organism:
Mycolicibacterium phlei
NCBI taxonomy Id: 1771
Other names: ATCC 11758, Bacterium phlei, CCUG 21000, CIP 105389, DSM 43239, JCM 5865, JCM 6385, M. phlei, Mycobacterium phlei, NCTC 8151, NRRL B-14615, Sclerothrix phlei
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.