STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdcBL-threonine dehydratase catabolic TdcB. (343 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase small subunit.
  
 
 0.849
ilvB1
Acetolactate synthase large subunit IlvB1.
 
 0.778
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.751
ilvD_2
Dihydroxy-acid dehydratase.
 
  
 0.706
ilvD_1
Dihydroxy-acid dehydratase.
 
  
 0.701
ilvD_3
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.693
ilvE
Branched-chain-amino-acid aminotransferase.
  
  
 0.638
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.619
gbh_1
Guanidinobutyrase.
  
  
 0.612
hom
Homoserine dehydrogenase.
  
  
 0.606
Your Current Organism:
Mycolicibacterium phlei
NCBI taxonomy Id: 1771
Other names: ATCC 11758, Bacterium phlei, CCUG 21000, CIP 105389, DSM 43239, JCM 5865, JCM 6385, M. phlei, Mycobacterium phlei, NCTC 8151, NRRL B-14615, Sclerothrix phlei
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.