STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1755 aa)    
Predicted Functional Partners:
TOP1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.955
SMC2
Structural maintenance of chromosomes protein.
   
 
 0.937
SUMO3
Small ubiquitin-related modifier 3.
    
 0.885
UBC11
Ubc11 protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.885
DL546_005776
Structural maintenance of chromosomes protein.
   
 
 0.862
UBC9
E2 SUMO-conjugating protein ubc9; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.855
SIZ1
SUMO ligase siz1.
    
 0.854
DL546_000677
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.851
CIN8
Kinesin motor protein cin8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.845
SMC6
Structural maintenance of chromosomes protein 6.
   
 
 0.821
Your Current Organism:
Coniochaeta pulveracea
NCBI taxonomy Id: 177199
Other names: C. pulveracea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.