node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCW61131.1 | SCW91102.1 | SAMN05660859_1986 | SAMN05660859_3700 | ATP phosphoribosyltransferase regulatory subunit. | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 0.976 |
SCW61131.1 | hisA | SAMN05660859_1986 | SAMN05660859_2532 | ATP phosphoribosyltransferase regulatory subunit. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.937 |
SCW61131.1 | hisB | SAMN05660859_1986 | SAMN05660859_2535 | ATP phosphoribosyltransferase regulatory subunit. | Imidazoleglycerol-phosphate dehydratase. | 0.952 |
SCW61131.1 | hisC | SAMN05660859_1986 | SAMN05660859_3521 | ATP phosphoribosyltransferase regulatory subunit. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.893 |
SCW61131.1 | hisE | SAMN05660859_1986 | SAMN05660859_2530 | ATP phosphoribosyltransferase regulatory subunit. | phosphoribosyl-ATP pyrophosphatase. | 0.992 |
SCW61131.1 | hisF | SAMN05660859_1986 | SAMN05660859_2531 | ATP phosphoribosyltransferase regulatory subunit. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.976 |
SCW61131.1 | hisG | SAMN05660859_1986 | SAMN05660859_1985 | ATP phosphoribosyltransferase regulatory subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
SCW61131.1 | hisH | SAMN05660859_1986 | SAMN05660859_2533 | ATP phosphoribosyltransferase regulatory subunit. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.936 |
SCW61131.1 | hisI | SAMN05660859_1986 | SAMN05660859_0979 | ATP phosphoribosyltransferase regulatory subunit. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.971 |
SCW61131.1 | hisS | SAMN05660859_1986 | SAMN05660859_1987 | ATP phosphoribosyltransferase regulatory subunit. | histidyl-tRNA synthetase. | 0.906 |
SCW91102.1 | SCW61131.1 | SAMN05660859_3700 | SAMN05660859_1986 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | ATP phosphoribosyltransferase regulatory subunit. | 0.976 |
SCW91102.1 | hisA | SAMN05660859_3700 | SAMN05660859_2532 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.962 |
SCW91102.1 | hisB | SAMN05660859_3700 | SAMN05660859_2535 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Imidazoleglycerol-phosphate dehydratase. | 0.950 |
SCW91102.1 | hisC | SAMN05660859_3700 | SAMN05660859_3521 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.871 |
SCW91102.1 | hisE | SAMN05660859_3700 | SAMN05660859_2530 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | phosphoribosyl-ATP pyrophosphatase. | 0.777 |
SCW91102.1 | hisF | SAMN05660859_3700 | SAMN05660859_2531 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.906 |
SCW91102.1 | hisG | SAMN05660859_3700 | SAMN05660859_1985 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.984 |
SCW91102.1 | hisH | SAMN05660859_3700 | SAMN05660859_2533 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.926 |
SCW91102.1 | hisI | SAMN05660859_3700 | SAMN05660859_0979 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.986 |
SCW91102.1 | hisS | SAMN05660859_3700 | SAMN05660859_1987 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | histidyl-tRNA synthetase. | 0.634 |