node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCW35510.1 | SCW61097.1 | SAMN05660859_0762 | SAMN05660859_1984 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.678 |
SCW35510.1 | SCW80473.1 | SAMN05660859_0762 | SAMN05660859_2950 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Nitroreductase. | 0.479 |
SCW35510.1 | SCW87989.1 | SAMN05660859_0762 | SAMN05660859_3442 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.548 |
SCW35510.1 | SCW93801.1 | SAMN05660859_0762 | SAMN05660859_4017 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. | 0.679 |
SCW35510.1 | SCW93834.1 | SAMN05660859_0762 | SAMN05660859_4023 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Amino acid adenylation domain-containing protein. | 0.864 |
SCW43258.1 | SCW80473.1 | SAMN05660859_1172 | SAMN05660859_2950 | NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family. | Nitroreductase. | 0.617 |
SCW43258.1 | SCW93801.1 | SAMN05660859_1172 | SAMN05660859_4017 | NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family. | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. | 0.899 |
SCW43258.1 | SCW93834.1 | SAMN05660859_1172 | SAMN05660859_4023 | NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family. | Amino acid adenylation domain-containing protein. | 0.976 |
SCW61097.1 | SCW35510.1 | SAMN05660859_1984 | SAMN05660859_0762 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.678 |
SCW61097.1 | SCW80473.1 | SAMN05660859_1984 | SAMN05660859_2950 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitroreductase. | 0.865 |
SCW61097.1 | SCW87989.1 | SAMN05660859_1984 | SAMN05660859_3442 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Glutamate synthase (NADPH/NADH) large chain. | 0.532 |
SCW80465.1 | SCW80473.1 | SAMN05660859_2949 | SAMN05660859_2950 | Hypothetical protein. | Nitroreductase. | 0.508 |
SCW80473.1 | SCW35510.1 | SAMN05660859_2950 | SAMN05660859_0762 | Nitroreductase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.479 |
SCW80473.1 | SCW43258.1 | SAMN05660859_2950 | SAMN05660859_1172 | Nitroreductase. | NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family. | 0.617 |
SCW80473.1 | SCW61097.1 | SAMN05660859_2950 | SAMN05660859_1984 | Nitroreductase. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.865 |
SCW80473.1 | SCW80465.1 | SAMN05660859_2950 | SAMN05660859_2949 | Nitroreductase. | Hypothetical protein. | 0.508 |
SCW80473.1 | SCW87989.1 | SAMN05660859_2950 | SAMN05660859_3442 | Nitroreductase. | Glutamate synthase (NADPH/NADH) large chain. | 0.473 |
SCW80473.1 | SCW91871.1 | SAMN05660859_2950 | SAMN05660859_3752 | Nitroreductase. | ABC-2 type transport system permease protein. | 0.484 |
SCW80473.1 | SCW93801.1 | SAMN05660859_2950 | SAMN05660859_4017 | Nitroreductase. | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. | 0.600 |
SCW80473.1 | SCW93834.1 | SAMN05660859_2950 | SAMN05660859_4023 | Nitroreductase. | Amino acid adenylation domain-containing protein. | 0.738 |