SCW87595.1 protein (Ancylobacter rudongensis)

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Known Interactions

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Predicted Interactions

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Score

SCW87595.1

Lactoylglutathione lyase. (131 aa)

Predicted Functional Partners:

gloB

0.947

SCW47854.1

0.896

SCW35759.1

0.883

SCW87604.1

0.813

trpB

0.792

SCW53073.1

0.778

SCW38424.1

0.772

SCW87614.1

0.763

SCW95074.1

0.696

SCW87583.1

0.686

Your Current Organism:

Ancylobacter rudongensis

NCBI taxonomy Id: 177413
Other names: A. rudongensis, Ancylobacter rudongensis Xin et al. 2004, JCM 11671

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCW35759.1	SCW47854.1	SAMN05660859_0775	SAMN05660859_1417	Glyoxylase, beta-lactamase superfamily II.	Lactoylglutathione lyase.	0.909
SCW35759.1	SCW87595.1	SAMN05660859_0775	SAMN05660859_3409	Glyoxylase, beta-lactamase superfamily II.	Lactoylglutathione lyase.	0.883
SCW35759.1	SCW95074.1	SAMN05660859_0775	SAMN05660859_4234	Glyoxylase, beta-lactamase superfamily II.	Propane monooxygenase reductase subunit.	0.649
SCW35759.1	gloB	SAMN05660859_0775	SAMN05660859_3424	Glyoxylase, beta-lactamase superfamily II.	Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.	0.914
SCW38424.1	SCW47854.1	SAMN05660859_0911	SAMN05660859_1417	Threonine dehydratase.	Lactoylglutathione lyase.	0.783
SCW38424.1	SCW87595.1	SAMN05660859_0911	SAMN05660859_3409	Threonine dehydratase.	Lactoylglutathione lyase.	0.772
SCW38424.1	trpB	SAMN05660859_0911	SAMN05660859_2381	Threonine dehydratase.	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.929
SCW47854.1	SCW35759.1	SAMN05660859_1417	SAMN05660859_0775	Lactoylglutathione lyase.	Glyoxylase, beta-lactamase superfamily II.	0.909
SCW47854.1	SCW38424.1	SAMN05660859_1417	SAMN05660859_0911	Lactoylglutathione lyase.	Threonine dehydratase.	0.783
SCW47854.1	SCW53073.1	SAMN05660859_1417	SAMN05660859_1455	Lactoylglutathione lyase.	methylmalonyl-CoA mutase.	0.778
SCW47854.1	SCW87595.1	SAMN05660859_1417	SAMN05660859_3409	Lactoylglutathione lyase.	Lactoylglutathione lyase.	0.896
SCW47854.1	SCW95074.1	SAMN05660859_1417	SAMN05660859_4234	Lactoylglutathione lyase.	Propane monooxygenase reductase subunit.	0.696
SCW47854.1	gloB	SAMN05660859_1417	SAMN05660859_3424	Lactoylglutathione lyase.	Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.	0.974
SCW47854.1	trpB	SAMN05660859_1417	SAMN05660859_2381	Lactoylglutathione lyase.	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.828
SCW53073.1	SCW47854.1	SAMN05660859_1455	SAMN05660859_1417	methylmalonyl-CoA mutase.	Lactoylglutathione lyase.	0.778
SCW53073.1	SCW87595.1	SAMN05660859_1455	SAMN05660859_3409	methylmalonyl-CoA mutase.	Lactoylglutathione lyase.	0.778
SCW87583.1	SCW87595.1	SAMN05660859_3408	SAMN05660859_3409	Predicted DNA-binding protein, contains Ribbon-helix-helix (RHH) domain.	Lactoylglutathione lyase.	0.686
SCW87583.1	SCW87604.1	SAMN05660859_3408	SAMN05660859_3410	Predicted DNA-binding protein, contains Ribbon-helix-helix (RHH) domain.	Hypothetical protein.	0.846
SCW87583.1	SCW87614.1	SAMN05660859_3408	SAMN05660859_3411	Predicted DNA-binding protein, contains Ribbon-helix-helix (RHH) domain.	Choline dehydrogenase.	0.826
SCW87595.1	SCW35759.1	SAMN05660859_3409	SAMN05660859_0775	Lactoylglutathione lyase.	Glyoxylase, beta-lactamase superfamily II.	0.883

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Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.822

expected number of edges:

7

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

6 of 8

2.58

5.47

1.97e-11

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 22

2.21

4.91

1.97e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 170

1.38

2.12

1.19e-08

GO:0006520

Cellular amino acid metabolic process

9 of 265

1.24

1.79

6.71e-09

GO:1901605

Alpha-amino acid metabolic process

7 of 191

1.27

1.63

1.03e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 143

1.33

1.38

0.00010

GO:0046820

4-amino-4-deoxychorismate synthase activity

2 of 2

2.71

1.14

0.0084

GO:0004834

Tryptophan synthase activity

2 of 3

2.53

1.14

0.0084

GO:0004048

Anthranilate phosphoribosyltransferase activity

2 of 2

2.71

1.14

0.0084

GO:0016835

Carbon-oxygen lyase activity

3 of 64

1.38

0.65

0.0401

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

Aromatic amino acid biosynthesis, and DAHP synthetase I/KDSA

10 of 19

2.43

8.78

3.27e-20

CL:2307

Tryptophan biosynthesis

6 of 6

2.71

6.06

2.08e-12

CL:2211

Mixed, incl. Amino-acid biosynthesis, and Vitamin B6 binding

11 of 94

1.78

4.87

1.82e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

7 of 34

2.02

4.43

2.83e-11

map01230

Biosynthesis of amino acids

8 of 205

1.3

1.86

3.81e-08

map00790

Folate biosynthesis

3 of 56

1.44

0.98

0.0058

map01110

Biosynthesis of secondary metabolites

8 of 771

0.72

0.6

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1516

0.53

0.39

0.0053

GOCC:0005622

Intracellular

11 of 2067

0.43

0.34

0.0053

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

7 of 8

2.65

7.17

6.53e-15

KW-0057

Aromatic amino acid biosynthesis

8 of 18

2.36

6.75

2.25e-15

KW-0028

Amino-acid biosynthesis

9 of 69

1.82

4.49

4.62e-14

KW-0456

Lyase

6 of 92

1.52

2.16

5.61e-07

KW-0315

Glutamine amidotransferase

2 of 14

1.86

0.91

0.0178

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

3 of 3

2.71

2.22

8.21e-05

PF00425

Chorismate binding enzyme

3 of 4

2.58

2.2

8.21e-05

PF00591

Glycosyl transferase family, a/b domain

2 of 3

2.53

1.13

0.0085

PF07722

Peptidase C26

2 of 5

2.31

1.01

0.0134

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019999

Anthranilate synthase component I-like

3 of 3

2.71

2.01

0.00021

IPR006805

Anthranilate synthase component I, N-terminal

3 of 3

2.71

2.01

0.00021

IPR015890

Chorismate-utilising enzyme, C-terminal

3 of 4

2.58

1.99

0.00021

IPR005801

ADC synthase

3 of 4

2.58

1.99

0.00021

IPR006221

Anthranilate synthase/para-aminobenzoate synthase like domain

2 of 2

2.71

1.16

0.0078

(more ...)

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