STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyoEProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (282 aa)    
Predicted Functional Partners:
cyoA
Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA: opt: 956 Z-score: 1145.6 E(): 6.4e-56 Smith-Waterman score: 956; 49.477 identity in 287 aa overlap.
 
 
 0.999
cyoB
Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA: opt: 3045 Z-score: 3221.2 E(): 1.6e-171 Smith-Waterman score: 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family.
 
 0.999
cyoC
Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA: opt: 768 Z-score: 931.9 E(): 5.1e-44 Smith-Waterman score: 768; 55.276identity in 199 aa overlap.
 
 
 0.999
cyoD
Similar to Q8ZC55 Cytochrome O ubiquinol oxidase subunit IV from Yersinia pestis (110 aa). FASTA: opt: 325 Z-score: 419.7 E(): 1.7e-15 Smith-Waterman score: 325; 50.505 identity in 99 aa overlap.
 
 
 0.997
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
   
 
 0.928
fadE
Similar to Q87QC0 Oxidoreductase, acyl-CoA dehydrogenase from Vibrio parahaemolyticus (760 aa). FASTA: opt: 2322 Z-score: 2681.1 E(): 1.7e-141 Smith-Waterman score: 2333; 46.817 identity in 754 aa overlap.
      
 0.795
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.670
fadA
Similar to Q8PKZ4 3-ketoacyl-CoA thiolase from Xanthomonas axonopodis (401 aa). FASTA: opt: 1586 Z-score: 1755.7 E(): 6.1e-90 Smith-Waterman score: 1586; 61.616 identity in 396 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family.
      
 0.602
hemE
Chelatase family protein, pseudogene; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
   
 0.447
sucA
Similar to Q883Z7 2-oxoglutarate dehydrogenase, E1 component from Pseudomonas syringae (943 aa). FASTA: opt: 3013 Z-score: 3478.7 E(): 7.1e-186 Smith-Waterman score: 3013; 49.523 identity in 943 aa overlap.
   
  
 0.440
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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