Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

cyoE

Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily (282 aa)

Predicted Functional Partners:

cyoB

0.999

cyoC

0.998

cyoD

0.997

cyoA

0.995

hemH

0.947

polA

0.864

hemF

0.596

hemE

0.589

ppdK

0.571

acpP

0.552

Your Current Organism:

Francisella tularensis SCHUS4

NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis SCHUS4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acpP	cyoE	FTT_1376	FTT_0285	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis	Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily	0.552
acpP	hemE	FTT_1376	FTT_0047	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.497
acpP	polA	FTT_1376	FTT_0111	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.597
acpP	ppdK	FTT_1376	FTT_0250	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis	Pyruvate, phosphate dikinase; Similar to Q8RB43 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase from Thermoanaerobacter tengcongensis (875 aa). FASTA- opt- 3545 Z-score- 4080.1 E()- 0 Smith-Waterman score- 3545; 61.812 identity in 872 aa overlap; Belongs to the PEP-utilizing enzyme family	0.607
cyoA	cyoB	FTT_0281	FTT_0282	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	0.999
cyoA	cyoC	FTT_0281	FTT_0283	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	0.999
cyoA	cyoD	FTT_0281	FTT_0284	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	Similar to Q8ZC55 Cytochrome O ubiquinol oxidase subunit IV from Yersinia pestis (110 aa). FASTA- opt- 325 Z-score- 419.7 E()- 1.7e-15 Smith-Waterman score- 325; 50.505 identity in 99 aa overlap	0.999
cyoA	cyoE	FTT_0281	FTT_0285	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily	0.995
cyoA	hemE	FTT_0281	FTT_0047	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.481
cyoB	cyoA	FTT_0282	FTT_0281	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	0.999
cyoB	cyoC	FTT_0282	FTT_0283	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	0.999
cyoB	cyoD	FTT_0282	FTT_0284	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	Similar to Q8ZC55 Cytochrome O ubiquinol oxidase subunit IV from Yersinia pestis (110 aa). FASTA- opt- 325 Z-score- 419.7 E()- 1.7e-15 Smith-Waterman score- 325; 50.505 identity in 99 aa overlap	0.999
cyoB	cyoE	FTT_0282	FTT_0285	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily	0.999
cyoB	hemE	FTT_0282	FTT_0047	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.488
cyoB	polA	FTT_0282	FTT_0111	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.487
cyoC	cyoA	FTT_0283	FTT_0281	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA- opt- 956 Z-score- 1145.6 E()- 6.4e-56 Smith-Waterman score- 956; 49.477 identity in 287 aa overlap	0.999
cyoC	cyoB	FTT_0283	FTT_0282	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA- opt- 3045 Z-score- 3221.2 E()- 1.6e-171 Smith-Waterman score- 3045; 64.361identity in 665 aa overlap; Belongs to the heme-copper respiratory oxidase family	0.999
cyoC	cyoD	FTT_0283	FTT_0284	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	Similar to Q8ZC55 Cytochrome O ubiquinol oxidase subunit IV from Yersinia pestis (110 aa). FASTA- opt- 325 Z-score- 419.7 E()- 1.7e-15 Smith-Waterman score- 325; 50.505 identity in 99 aa overlap	0.999
cyoC	cyoE	FTT_0283	FTT_0285	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily	0.998
cyoC	hemE	FTT_0283	FTT_0047	Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA- opt- 768 Z-score- 931.9 E()- 5.1e-44 Smith-Waterman score- 768; 55.276identity in 199 aa overlap	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.542

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