STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FTT_0645cSimilar to YCCA_ECOLI (P06967) Hypothetical protein yccA from Escherichia coli (219 aa). FASTA: opt: 588 Z-score: 603.2 E(): 1.1e-25 Smith-Waterman score: 588; 48.416 identity in 221 aa overlap. ORF ftt0645c; Belongs to the BI1 family. (228 aa)    
Predicted Functional Partners:
mfd
Ketol-acid reductoisomerase, pseudogene; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
       0.636
rnfB
Iron-sulfur cluster-binding protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
     0.579
msrA1
Major facilitator superfamily (MFS) transport protein, pseudogene; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
 
   0.538
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
       0.512
FTT_0646c
Hypothetical membrane protein; ORF ftt0646c.
       0.509
FTT_0647c
Similar to Q82WE7 Hypothetical protein from Nitrosomonas europaea (164 aa). FASTA: opt: 383 Z-score: 490.4 E(): 2e-19 Smith-Waterman score: 383; 41.606 identity in 137 aa overlap. ORF ftt0647c.
       0.509
grxB
Similar to Q9CNB4 Grx2 from Pasteurella multocida (215 aa). FASTA: opt: 412 Z-score: 518.8 E(): 5.3e-21 Smith-Waterman score: 412; 32.243 identity in 214 aa overlap.
       0.509
htpX
Similar to Q83DZ2 Heat shock protein HtpX from Coxiella burnetii (348 aa). FASTA: opt: 956 Z-score: 1111.3 E(): 5.2e-54 Smith-Waterman score: 1062; 47.091 identity in 361 aa overlap.
  
  
 0.482
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.