node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACN14952.1 | upp | HRM2_18500 | HRM2_05330 | Oxidoreductase (3-oxoacyl-[acyl-carrier-protein] reductase). | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.893 |
codA | pyrR | HRM2_46240 | HRM2_09210 | CodA; Cytosine deaminase CodA. | PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.913 |
codA | upp | HRM2_46240 | HRM2_05330 | CodA; Cytosine deaminase CodA. | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.945 |
glyA | guaA1 | HRM2_31300 | HRM2_18870 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GuaA1; Catalyzes the synthesis of GMP from XMP. | 0.644 |
glyA | pyrF | HRM2_31300 | HRM2_35880 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.440 |
glyA | rpiB | HRM2_31300 | HRM2_31310 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | RpiB; Ribose-5-phosphate isomerase RpiB (phosphoriboisomerase B). | 0.983 |
glyA | upp | HRM2_31300 | HRM2_05330 | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.894 |
guaA1 | glyA | HRM2_18870 | HRM2_31300 | GuaA1; Catalyzes the synthesis of GMP from XMP. | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.644 |
guaA1 | pyrF | HRM2_18870 | HRM2_35880 | GuaA1; Catalyzes the synthesis of GMP from XMP. | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.632 |
guaA1 | pyrH | HRM2_18870 | HRM2_17120 | GuaA1; Catalyzes the synthesis of GMP from XMP. | PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.722 |
guaA1 | pyrR | HRM2_18870 | HRM2_09210 | GuaA1; Catalyzes the synthesis of GMP from XMP. | PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.510 |
guaA1 | rpiB | HRM2_18870 | HRM2_31310 | GuaA1; Catalyzes the synthesis of GMP from XMP. | RpiB; Ribose-5-phosphate isomerase RpiB (phosphoriboisomerase B). | 0.472 |
guaA1 | upp | HRM2_18870 | HRM2_05330 | GuaA1; Catalyzes the synthesis of GMP from XMP. | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.946 |
guaA1 | uraA | HRM2_18870 | HRM2_05320 | GuaA1; Catalyzes the synthesis of GMP from XMP. | UraA; Uracil permease UraA (uracil/xanthine permease family protein). | 0.594 |
guaA1 | ushA | HRM2_18870 | HRM2_09650 | GuaA1; Catalyzes the synthesis of GMP from XMP. | UshA; UDP-sugar hydrolase / 5'-nucleotidase UshA [precursor]; Belongs to the 5'-nucleotidase family. | 0.919 |
pyrF | glyA | HRM2_35880 | HRM2_31300 | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.440 |
pyrF | guaA1 | HRM2_35880 | HRM2_18870 | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | GuaA1; Catalyzes the synthesis of GMP from XMP. | 0.632 |
pyrF | pyrH | HRM2_35880 | HRM2_17120 | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.935 |
pyrF | pyrR | HRM2_35880 | HRM2_09210 | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.990 |
pyrF | upp | HRM2_35880 | HRM2_05330 | PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.949 |