STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppUpp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)    
Predicted Functional Partners:
pyrH
PyrH; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.962
pyrF
PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.949
guaA1
GuaA1; Catalyzes the synthesis of GMP from XMP.
  
  
 0.946
codA
CodA; Cytosine deaminase CodA.
  
 
 0.945
uraA
UraA; Uracil permease UraA (uracil/xanthine permease family protein).
  
 0.938
pyrR
PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
     
 0.934
rpiB
RpiB; Ribose-5-phosphate isomerase RpiB (phosphoriboisomerase B).
 
  
 0.922
ushA
UshA; UDP-sugar hydrolase / 5'-nucleotidase UshA [precursor]; Belongs to the 5'-nucleotidase family.
     
 0.905
glyA
GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.894
ACN14952.1
Oxidoreductase (3-oxoacyl-[acyl-carrier-protein] reductase).
 
 
  
 0.893
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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